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• W2896035179 abstract "The ongoing, and very serious, threat from antimicrobial resistance necessitates the development and use of preventative measures, predominantly vaccination. Polysaccharide-based vaccines have provided a degree of success in limiting morbidity from disseminated bacterial infections, including those caused by the major human obligate pathogens, Neisseria meningitidis and Streptococcus pneumoniae. Limitations of these polysaccharide vaccines, such as partial coverage and induced escape leading to persistence of disease, provide a compelling argument for the development of protein vaccines. In this review, we briefly chronicle approaches that have yielded licensed vaccines before highlighting reverse vaccinology 2.0 and its potential application in the discovery of novel bacterial protein vaccine candidates. Technical challenges and research gaps are also discussed." @default.
• W2896035179 created "2018-10-26" @default.
• W2896035179 creator A5006632020 @default.
• W2896035179 creator A5023693692 @default.
• W2896035179 creator A5026715428 @default.
• W2896035179 creator A5073532400 @default.
• W2896035179 date "2018-10-08" @default.
• W2896035179 modified "2023-10-14" @default.
• W2896035179 title "Bacterial Vaccine Antigen Discovery in the Reverse Vaccinology 2.0 Era: Progress and Challenges" @default.
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• W2896035179 doi "https://doi.org/10.3389/fimmu.2018.02315" @default.
• W2896035179 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6187972" @default.
• W2896035179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30349542" @default.
• W2896035179 hasPublicationYear "2018" @default.
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