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• W2896036432 endingPage "270" @default.
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• W2896036432 abstract "miR-132 and miR-212 are structurally-related microRNAs that are expressed from the same non-coding transcript. Accumulating evidence has shown that the dysregulation of these microRNAs contributes to aberrant neuronal plasticity and gene expression in the mammalian brain. Consistent with this, altered expression of miR-132 is associated with a number of affect-related psychiatric disorders. Here, we tested the functional contribution of the miR-132/212 locus to the development of stress-related and anxiety-like behaviors. Initially, we tested whether expression from the miR-132/212 locus is altered by stress-inducing paradigms. Using a 5-h acute-stress model, we show that both miR-132 and miR-212 are increased more than two-fold in the WT murine hippocampus and amygdala, whereas after a 15 day chronic-stress paradigm, expression of both miR-132 and miR-212 are upregulated more than two-fold within the amygdala but not in the hippocampus. Next, we used a tetracycline-inducible miR-132 overexpression mouse model and a miR-132/212 conditional knockout (cKO) mouse model to examine whether dysregulation of miR-132/212 expression alters basal anxiety-like behaviors. Interestingly, in both the miR-132 overexpression and cKO lines, significant increases in anxiety-like behaviors were detected. Importantly, suppression of transgenic miR-132 expression (via doxycycline administration) mitigated the anxiety-related behaviors. Further, expression of Sirt1 and Pten-two miR-132 target genes that have been implicated in the regulation of anxiety-were differentially regulated in the hippocampus and amygdala of miR-132/212 conditional knockout and miR-132 transgenic mice. Collectively, these data raise the prospect that miR-132 and miR-212 may play a key role in the modulation of stress responsivity and anxiety." @default.
• W2896036432 created "2018-10-26" @default.
• W2896036432 creator A5004798073 @default.
• W2896036432 creator A5013842386 @default.
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• W2896036432 creator A5065364589 @default.
• W2896036432 creator A5071083284 @default.
• W2896036432 creator A5087779277 @default.
• W2896036432 date "2019-01-01" @default.
• W2896036432 modified "2023-10-10" @default.
• W2896036432 title "miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior" @default.
• W2896036432 cites W1547865271 @default.
• W2896036432 cites W1558137567 @default.
• W2896036432 cites W1588326306 @default.
• W2896036432 cites W1722767087 @default.
• W2896036432 cites W1804267428 @default.
• W2896036432 cites W1840860792 @default.
• W2896036432 cites W1892663292 @default.
• W2896036432 cites W1908945397 @default.
• W2896036432 cites W1964160578 @default.
• W2896036432 cites W1968479555 @default.
• W2896036432 cites W1968631483 @default.
• W2896036432 cites W1969931608 @default.
• W2896036432 cites W1971940265 @default.
• W2896036432 cites W1973643970 @default.
• W2896036432 cites W1977028183 @default.
• W2896036432 cites W1978922003 @default.
• W2896036432 cites W1980677407 @default.
• W2896036432 cites W1983494600 @default.
• W2896036432 cites W1983633003 @default.
• W2896036432 cites W1983720336 @default.
• W2896036432 cites W1987900652 @default.
• W2896036432 cites W1991660337 @default.
• W2896036432 cites W1995621192 @default.
• W2896036432 cites W2000430854 @default.
• W2896036432 cites W2006472411 @default.
• W2896036432 cites W2006831423 @default.
• W2896036432 cites W2007835395 @default.
• W2896036432 cites W2008301991 @default.
• W2896036432 cites W2009487673 @default.
• W2896036432 cites W2014508548 @default.
• W2896036432 cites W2015284016 @default.
• W2896036432 cites W2015431173 @default.
• W2896036432 cites W2017097994 @default.
• W2896036432 cites W2017446057 @default.
• W2896036432 cites W2017968071 @default.
• W2896036432 cites W2022221011 @default.
• W2896036432 cites W2022798217 @default.
• W2896036432 cites W2023963419 @default.
• W2896036432 cites W2024583667 @default.
• W2896036432 cites W2028222586 @default.
• W2896036432 cites W2029505958 @default.
• W2896036432 cites W2033884201 @default.
• W2896036432 cites W2038579165 @default.
• W2896036432 cites W2041749675 @default.
• W2896036432 cites W2044404835 @default.
• W2896036432 cites W2053967275 @default.
• W2896036432 cites W2057308155 @default.
• W2896036432 cites W2057436796 @default.
• W2896036432 cites W2061092474 @default.
• W2896036432 cites W2067144095 @default.
• W2896036432 cites W2067487957 @default.
• W2896036432 cites W2068376740 @default.
• W2896036432 cites W2069256720 @default.
• W2896036432 cites W2075043109 @default.
• W2896036432 cites W2075522824 @default.
• W2896036432 cites W2079673196 @default.
• W2896036432 cites W2080137338 @default.
• W2896036432 cites W2082251914 @default.
• W2896036432 cites W2083822954 @default.
• W2896036432 cites W2084070063 @default.
• W2896036432 cites W2087864817 @default.
• W2896036432 cites W2089233932 @default.
• W2896036432 cites W2090100345 @default.
• W2896036432 cites W2091410656 @default.
• W2896036432 cites W2091497325 @default.
• W2896036432 cites W2094951488 @default.
• W2896036432 cites W2095972118 @default.
• W2896036432 cites W2097357554 @default.
• W2896036432 cites W2099004076 @default.
• W2896036432 cites W2102226828 @default.
• W2896036432 cites W2104463303 @default.
• W2896036432 cites W2110747672 @default.
• W2896036432 cites W2112797721 @default.
• W2896036432 cites W2117391623 @default.
• W2896036432 cites W2118576081 @default.
• W2896036432 cites W2119322430 @default.
• W2896036432 cites W2122727530 @default.
• W2896036432 cites W2124759835 @default.
• W2896036432 cites W2125716823 @default.
• W2896036432 cites W2130779240 @default.
• W2896036432 cites W2133659563 @default.
• W2896036432 cites W2136403062 @default.
• W2896036432 cites W2137811349 @default.
• W2896036432 cites W2149099231 @default.
• W2896036432 cites W2151046665 @default.

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