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- W2896038602 abstract "Abstract Aging leads to gray and white matter decline but their causation remains unclear. We explored two broad classes of models of age and dementia risk related brain changes. The first class of models emphasises the importance of gray matter: age and risk-related processes cause neurodegeneration and this causes damage in associated white matter tracts. The second class of models reverses the direction of causation: aging and risk factors cause white matter damage and this leads to gray matter damage. We compared these models with linear mediation analysis and quantitative multi-modal MRI indices (from diffusion, quantitative magnetization transfer and relaxometry imaging) of tissue properties in two limbic structures implicated in age-related memory decline: the hippocampus and the fornix in 166 asymptomatic individuals (aged 38 - 71 years). Aging was associated with apparent glia but not axon density damage in the fornix. Mediation analysis unambiguously supported white matter damage causing gray matter decline; controlling for fornix glia damage, the correlation between age and hippocampal damage disappears, but not vice versa . Fornix and hippocampal tissue loss were both associated with reductions in episodic memory performance. The implications of these findings for neuroglia and neurodegenerative models of aging and late onset dementia are discussed." @default.
- W2896038602 created "2018-10-26" @default.
- W2896038602 creator A5005207240 @default.
- W2896038602 creator A5008494200 @default.
- W2896038602 creator A5013550411 @default.
- W2896038602 creator A5015013345 @default.
- W2896038602 creator A5039589557 @default.
- W2896038602 creator A5040508278 @default.
- W2896038602 creator A5045685986 @default.
- W2896038602 creator A5088676733 @default.
- W2896038602 date "2018-10-11" @default.
- W2896038602 modified "2023-09-23" @default.
- W2896038602 title "The causal structure of age-dependent limbic decline: fornix white matter glia damage causes hippocampal grey matter damage, not vice versa" @default.
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