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- W2896040217 startingPage "3100" @default.
- W2896040217 abstract "Otto Warburg, a Nobel prize winner, observed that cancer cells typically “switch” from aerobic to anaerobic respiration. He hypothesized that mitochondrial damage induces neoplastic transformation. In contrast, pathological aging is observed mainly in neuron cells in neurodegenerative diseases. Oxidative respiration is particularly active in neurons. There is inverse comorbidity between cancer and neurodegenerative diseases. This led to the creation of the “inverse Warburg hypothesis”, according to which excessive mitochondrial activity induces pathological aging. The findings of our studies suggest that both the Warburg effect and the “inverse Warburg hypothesis” can be elucidated by the activation or suppression of apoptosis through oxidative respiration. The key outcome of our phylogenetic studies was the discovery that apoptosis and apoptosis-like cell death evolved due to an evolutionary “arms race” conducted between “prey” protomitochondrion and “predator” primitive eukaryotes. The ancestral protomitochondrial machinery produces and releases toxic mitochondrial proteins. Extant apoptotic factors evolved from these toxins. Our experiments indicate that the mitochondrial machinery is directly involved in adaptation to aerobic conditions. Additionally, our hypothesis is supported by the fact that different apoptotic factors are directly involved in respiration." @default.
- W2896040217 created "2018-10-26" @default.
- W2896040217 creator A5020092699 @default.
- W2896040217 creator A5029849748 @default.
- W2896040217 creator A5078146179 @default.
- W2896040217 date "2018-10-10" @default.
- W2896040217 modified "2023-10-16" @default.
- W2896040217 title "An Apoptotic and Endosymbiotic Explanation of the Warburg and the Inverse Warburg Hypotheses" @default.
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