FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896041501> ?p ?o ?g. }

• W2896041501 endingPage "F1713" @default.
• W2896041501 startingPage "F1708" @default.
• W2896041501 abstract "Zucker obese rats (ZOR) have higher glomerular capillary pressure (PGC) that can cause renal damage. PGC is controlled by afferent (Af-Art) and efferent arteriole (Ef-Art) resistance. Af-Art resistance is regulated by factors that regulate other arterioles, such as myogenic response. In addition, it is also regulated by 2 intrinsic feedback mechanisms: 1) tubuloglomerular feedback (TGF) that causes Af-Art constriction in response to increased NaCl in the macula densa and 2) connecting tubule glomerular feedback (CTGF) that causes Af-Art dilatation in response to an increase in NaCl transport in the connecting tubule via the epithelial sodium channel. Since CTGF is an Af-Art dilatory mechanism, we hypothesized that increased CTGF contributes to TGF attenuation, which in turn increases PGC in ZOR. We performed a renal micropuncture experiment and measured stop-flow pressure (PSF), which is an indirect measurement of PGC in ZOR. Maximal TGF response at 40 nl/min was attenuated in ZOR (4.47 ± 0.60 mmHg) in comparison to the Zucker lean rats (ZLR; 8.54 ± 0.73 mmHg, P < 0.05), and CTGF was elevated in ZOR (5.34 ± 0.87 mmHg) compared with ZLR (1.12 ± 1.28 mmHg, P < 0.05). CTGF inhibition with epithelial sodium channel blocker normalized the maximum PSF change in ZOR indicating that CTGF plays a significant role in TGF attenuation (ZOR, 10.67 ± 1.07 mmHg vs. ZLR, 9.5 ± 1.53 mmHg). We conclude that enhanced CTGF contributes to TGF attenuation in ZOR and potentially contribute to progressive renal damage." @default.
• W2896041501 created "2018-10-26" @default.
• W2896041501 creator A5012550823 @default.
• W2896041501 creator A5042687795 @default.
• W2896041501 creator A5061439030 @default.
• W2896041501 creator A5076892848 @default.
• W2896041501 date "2018-12-01" @default.
• W2896041501 modified "2023-10-02" @default.
• W2896041501 title "Role of connecting tubule glomerular feedback in obesity related renal damage" @default.
• W2896041501 cites W128742651 @default.
• W2896041501 cites W1605974962 @default.
• W2896041501 cites W1916626870 @default.
• W2896041501 cites W1984495234 @default.
• W2896041501 cites W1994318634 @default.
• W2896041501 cites W2004830232 @default.
• W2896041501 cites W2036673542 @default.
• W2896041501 cites W2036903959 @default.
• W2896041501 cites W2044654595 @default.
• W2896041501 cites W2075541781 @default.
• W2896041501 cites W2077156148 @default.
• W2896041501 cites W2078902399 @default.
• W2896041501 cites W2081474573 @default.
• W2896041501 cites W2083307866 @default.
• W2896041501 cites W2091031177 @default.
• W2896041501 cites W2101958816 @default.
• W2896041501 cites W2104040600 @default.
• W2896041501 cites W2117722012 @default.
• W2896041501 cites W2119138038 @default.
• W2896041501 cites W2125113680 @default.
• W2896041501 cites W2126273647 @default.
• W2896041501 cites W2127982963 @default.
• W2896041501 cites W2131165447 @default.
• W2896041501 cites W2134205277 @default.
• W2896041501 cites W2138029694 @default.
• W2896041501 cites W2145793381 @default.
• W2896041501 cites W2150977217 @default.
• W2896041501 cites W2155976167 @default.
• W2896041501 cites W2160489799 @default.
• W2896041501 cites W2167147553 @default.
• W2896041501 cites W2172579152 @default.
• W2896041501 cites W2327112682 @default.
• W2896041501 cites W2331954937 @default.
• W2896041501 cites W2413928743 @default.
• W2896041501 cites W2415080161 @default.
• W2896041501 cites W2416372302 @default.
• W2896041501 cites W2417782424 @default.
• W2896041501 cites W2593069017 @default.
• W2896041501 cites W2606573542 @default.
• W2896041501 cites W260849481 @default.
• W2896041501 cites W2616618686 @default.
• W2896041501 cites W2762007044 @default.
• W2896041501 doi "https://doi.org/10.1152/ajprenal.00227.2018" @default.
• W2896041501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6336995" @default.
• W2896041501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30303713" @default.
• W2896041501 hasPublicationYear "2018" @default.
• W2896041501 type Work @default.
• W2896041501 sameAs 2896041501 @default.
• W2896041501 citedByCount "5" @default.
• W2896041501 countsByYear W28960415012019 @default.
• W2896041501 countsByYear W28960415012022 @default.
• W2896041501 countsByYear W28960415012023 @default.
• W2896041501 crossrefType "journal-article" @default.
• W2896041501 hasAuthorship W2896041501A5012550823 @default.
• W2896041501 hasAuthorship W2896041501A5042687795 @default.
• W2896041501 hasAuthorship W2896041501A5061439030 @default.
• W2896041501 hasAuthorship W2896041501A5076892848 @default.
• W2896041501 hasBestOaLocation W28960415011 @default.
• W2896041501 hasConcept C126322002 @default.
• W2896041501 hasConcept C12722491 @default.
• W2896041501 hasConcept C134018914 @default.
• W2896041501 hasConcept C170493617 @default.
• W2896041501 hasConcept C185592680 @default.
• W2896041501 hasConcept C198710026 @default.
• W2896041501 hasConcept C2775960820 @default.
• W2896041501 hasConcept C2779482390 @default.
• W2896041501 hasConcept C2780091579 @default.
• W2896041501 hasConcept C2780631158 @default.
• W2896041501 hasConcept C2780636983 @default.
• W2896041501 hasConcept C2781236342 @default.
• W2896041501 hasConcept C71924100 @default.
• W2896041501 hasConcept C7643261 @default.
• W2896041501 hasConcept C84393581 @default.
• W2896041501 hasConceptScore W2896041501C126322002 @default.
• W2896041501 hasConceptScore W2896041501C12722491 @default.
• W2896041501 hasConceptScore W2896041501C134018914 @default.
• W2896041501 hasConceptScore W2896041501C170493617 @default.
• W2896041501 hasConceptScore W2896041501C185592680 @default.
• W2896041501 hasConceptScore W2896041501C198710026 @default.
• W2896041501 hasConceptScore W2896041501C2775960820 @default.
• W2896041501 hasConceptScore W2896041501C2779482390 @default.
• W2896041501 hasConceptScore W2896041501C2780091579 @default.
• W2896041501 hasConceptScore W2896041501C2780631158 @default.
• W2896041501 hasConceptScore W2896041501C2780636983 @default.
• W2896041501 hasConceptScore W2896041501C2781236342 @default.
• W2896041501 hasConceptScore W2896041501C71924100 @default.
• W2896041501 hasConceptScore W2896041501C7643261 @default.
• W2896041501 hasConceptScore W2896041501C84393581 @default.
• W2896041501 hasFunder F4320320334 @default.

• next