Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896042697> ?p ?o ?g. }
- W2896042697 endingPage "584" @default.
- W2896042697 startingPage "569" @default.
- W2896042697 abstract "Microgravity is one of the main threats to the health of astronauts. Pulsed electromagnetic fields (PEMFs) have been considered as one of the potential countermeasures for bone loss induced by space flight. However, the optimal therapeutic parameters of PEMFs have not been obtained and the action mechanism is still largely unknown. In this study, a set of optimal therapeutic parameters for PEMFs (50 Hz, 0.6 mT 50% duty cycle and 90 min/day) selected based on high‐throughput screening with cultured osteoblasts was used to prevent bone loss in rats induced by hindlimb suspension, a commonly accepted animal model to simulate the space environment. It was found that hindlimb suspension for 4 weeks led to significant decreases in femoral and vertebral bone mineral density (BMD) and their maximal loads, severe deterioration in bone micro‐structure, and decreases in levels of bone formation markers and increases in bone resorption markers. PEMF treatment prevented about 50% of the decreased BMD and maximal loads, preserved the microstructure of cancellous bone and thickness of cortical bone, and inhibited decreases in bone formation markers. Histological analyses revealed that PEMFs significantly alleviated the reduction in osteoblast number and inhibited the increase in adipocyte number in the bone marrow. PEMFs also blocked decreases in serum levels of parathyroid hormone and its downstream signal molecule cAMP, and maintained the phosphorylation levels of protein kinase A (PKA) and cAMP response element‐binding protein (CREB). The expression level of soluble adenylyl cyclases (sAC) was also maintained. It therefore can be concluded that PEMFs partially prevented the bone loss induced by weightless environment by maintaining bone formation through signaling of the sAC/cAMP/PKA/CREB pathway. Bioelectromagnetics. 39:569–584, 2018. © 2018 Wiley Periodicals, Inc." @default.
- W2896042697 created "2018-10-26" @default.
- W2896042697 creator A5003609077 @default.
- W2896042697 creator A5009858711 @default.
- W2896042697 creator A5026633464 @default.
- W2896042697 creator A5039636559 @default.
- W2896042697 creator A5065140987 @default.
- W2896042697 creator A5068095972 @default.
- W2896042697 creator A5068294695 @default.
- W2896042697 creator A5073999661 @default.
- W2896042697 creator A5085165889 @default.
- W2896042697 creator A5085841957 @default.
- W2896042697 date "2018-10-23" @default.
- W2896042697 modified "2023-09-25" @default.
- W2896042697 title "Pulsed electromagnetic fields prevented the decrease of bone formation in hindlimb-suspended rats by activating sAC/cAMP/PKA/CREB signaling pathway" @default.
- W2896042697 cites W1524656751 @default.
- W2896042697 cites W1909155825 @default.
- W2896042697 cites W1965840684 @default.
- W2896042697 cites W1968773749 @default.
- W2896042697 cites W1969945339 @default.
- W2896042697 cites W1970549929 @default.
- W2896042697 cites W1974606020 @default.
- W2896042697 cites W1974805573 @default.
- W2896042697 cites W1977489392 @default.
- W2896042697 cites W1981447788 @default.
- W2896042697 cites W1981701235 @default.
- W2896042697 cites W1982931874 @default.
- W2896042697 cites W1987571908 @default.
- W2896042697 cites W1987951717 @default.
- W2896042697 cites W1992567157 @default.
- W2896042697 cites W1994206981 @default.
- W2896042697 cites W1994692175 @default.
- W2896042697 cites W2001056852 @default.
- W2896042697 cites W2022086033 @default.
- W2896042697 cites W2022493848 @default.
- W2896042697 cites W2027575875 @default.
- W2896042697 cites W2031429499 @default.
- W2896042697 cites W2035131661 @default.
- W2896042697 cites W2037156220 @default.
- W2896042697 cites W2041236572 @default.
- W2896042697 cites W2056462211 @default.
- W2896042697 cites W2063075961 @default.
- W2896042697 cites W2079783701 @default.
- W2896042697 cites W2082634363 @default.
- W2896042697 cites W2093233192 @default.
- W2896042697 cites W2095148883 @default.
- W2896042697 cites W2096264857 @default.
- W2896042697 cites W2105334779 @default.
- W2896042697 cites W2124071177 @default.
- W2896042697 cites W2124668683 @default.
- W2896042697 cites W2136825553 @default.
- W2896042697 cites W2136871084 @default.
- W2896042697 cites W2144292634 @default.
- W2896042697 cites W2152765106 @default.
- W2896042697 cites W2154148361 @default.
- W2896042697 cites W2163898248 @default.
- W2896042697 cites W2171845781 @default.
- W2896042697 cites W2214388059 @default.
- W2896042697 cites W2284759896 @default.
- W2896042697 cites W2311061917 @default.
- W2896042697 cites W2343768450 @default.
- W2896042697 cites W2401326066 @default.
- W2896042697 cites W2555063845 @default.
- W2896042697 cites W2559570617 @default.
- W2896042697 cites W2578947349 @default.
- W2896042697 cites W2619099565 @default.
- W2896042697 cites W2621013787 @default.
- W2896042697 cites W2741378408 @default.
- W2896042697 cites W2756999633 @default.
- W2896042697 cites W2765765270 @default.
- W2896042697 cites W61996762 @default.
- W2896042697 doi "https://doi.org/10.1002/bem.22150" @default.
- W2896042697 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30350869" @default.
- W2896042697 hasPublicationYear "2018" @default.
- W2896042697 type Work @default.
- W2896042697 sameAs 2896042697 @default.
- W2896042697 citedByCount "8" @default.
- W2896042697 countsByYear W28960426972019 @default.
- W2896042697 countsByYear W28960426972021 @default.
- W2896042697 countsByYear W28960426972022 @default.
- W2896042697 crossrefType "journal-article" @default.
- W2896042697 hasAuthorship W2896042697A5003609077 @default.
- W2896042697 hasAuthorship W2896042697A5009858711 @default.
- W2896042697 hasAuthorship W2896042697A5026633464 @default.
- W2896042697 hasAuthorship W2896042697A5039636559 @default.
- W2896042697 hasAuthorship W2896042697A5065140987 @default.
- W2896042697 hasAuthorship W2896042697A5068095972 @default.
- W2896042697 hasAuthorship W2896042697A5068294695 @default.
- W2896042697 hasAuthorship W2896042697A5073999661 @default.
- W2896042697 hasAuthorship W2896042697A5085165889 @default.
- W2896042697 hasAuthorship W2896042697A5085841957 @default.
- W2896042697 hasConcept C104317684 @default.
- W2896042697 hasConcept C105702510 @default.
- W2896042697 hasConcept C11960822 @default.
- W2896042697 hasConcept C126322002 @default.
- W2896042697 hasConcept C134018914 @default.
- W2896042697 hasConcept C146562846 @default.
- W2896042697 hasConcept C1629964 @default.