FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896045114> ?p ?o ?g. }

• W2896045114 abstract "Aquaporin-4-immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorder (herein called NMO) is an autoimmune disease of the central nervous system in which AQP4-IgG binding to AQP4 on astrocytes results in complement-dependent astrocyte injury and secondary inflammation, demyelination, and neuron loss. We previously reported evidence for a complement bystander mechanism for early oligodendrocyte injury in NMO. Herein, we tested the hypothesis that complement bystander injury, which involves diffusion to nearby cells of activated soluble complement components from complement-injured astrocytes, is a general phenomenon that may contribute to neuronal injury in NMO. Primary cocultures of rat astrocytes and cortical neurons were established to study complement-dependent cell death after exposure to AQP4-IgG and complement. In animal experiments, AQP4-IgG was delivered to adult rats by intracerebral injection. Cell cultures and rat brain were studied by immunofluorescence. In primary astrocyte-neuron cocultures, addition of AQP4-IgG and complement resulted in death of neurons nearby astrocytes. Deposition of complement membrane attack complex C5b-9 was seen on neurons nearby astrocytes, whereas C1q, the initiating protein in the complement pathway, was seen only on astrocytes. Neuron death was not seen with a complement inhibitor, with C1q- or C6-depleted complement, in pure neuron cultures exposed to AQP4-IgG and complement or in cocultures exposed to an astrocyte toxin. Intracerebral injection in rats of AQP4-IgG and a fixable dead cell fluorescent marker produced death of neurons near astrocytes, with C5b-9 deposition. Neuron death was not seen in rats receiving a complement inhibitor or in AQP4-IgG-injected AQP4 knockout rats. These results support a novel mechanism for early neuron injury in NMO and provide evidence that complement bystander injury may be a general phenomenon for brain cell injury following AQP4-IgG-targeted astrocyte death." @default.
• W2896045114 created "2018-10-26" @default.
• W2896045114 creator A5018088664 @default.
• W2896045114 creator A5021197154 @default.
• W2896045114 creator A5042356327 @default.
• W2896045114 date "2018-10-22" @default.
• W2896045114 modified "2023-10-17" @default.
• W2896045114 title "Complement-dependent bystander injury to neurons in AQP4-IgG seropositive neuromyelitis optica" @default.
• W2896045114 cites W1492123500 @default.
• W2896045114 cites W1669254980 @default.
• W2896045114 cites W1930520388 @default.
• W2896045114 cites W1965467335 @default.
• W2896045114 cites W1982876448 @default.
• W2896045114 cites W1995354590 @default.
• W2896045114 cites W2000333763 @default.
• W2896045114 cites W2007556864 @default.
• W2896045114 cites W2009308901 @default.
• W2896045114 cites W2015868606 @default.
• W2896045114 cites W2017070092 @default.
• W2896045114 cites W2036172456 @default.
• W2896045114 cites W2048694754 @default.
• W2896045114 cites W2050217807 @default.
• W2896045114 cites W2051556653 @default.
• W2896045114 cites W2052960773 @default.
• W2896045114 cites W2053472907 @default.
• W2896045114 cites W2067325343 @default.
• W2896045114 cites W2069414099 @default.
• W2896045114 cites W2071602419 @default.
• W2896045114 cites W2077427574 @default.
• W2896045114 cites W2081767887 @default.
• W2896045114 cites W2092701076 @default.
• W2896045114 cites W2094805852 @default.
• W2896045114 cites W2104567100 @default.
• W2896045114 cites W2123936058 @default.
• W2896045114 cites W2127778297 @default.
• W2896045114 cites W2147444468 @default.
• W2896045114 cites W2156918730 @default.
• W2896045114 cites W2161681716 @default.
• W2896045114 cites W2188402976 @default.
• W2896045114 cites W2290972543 @default.
• W2896045114 cites W2344109506 @default.
• W2896045114 cites W2417929177 @default.
• W2896045114 cites W2559786446 @default.
• W2896045114 cites W2588998357 @default.
• W2896045114 cites W2617265115 @default.
• W2896045114 cites W2746870493 @default.
• W2896045114 cites W2783111346 @default.
• W2896045114 cites W2789545147 @default.
• W2896045114 cites W4231652458 @default.
• W2896045114 cites W64494300 @default.
• W2896045114 doi "https://doi.org/10.1186/s12974-018-1333-z" @default.
• W2896045114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6198534" @default.
• W2896045114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30348195" @default.
• W2896045114 hasPublicationYear "2018" @default.
• W2896045114 type Work @default.
• W2896045114 sameAs 2896045114 @default.
• W2896045114 citedByCount "53" @default.
• W2896045114 countsByYear W28960451142019 @default.
• W2896045114 countsByYear W28960451142020 @default.
• W2896045114 countsByYear W28960451142021 @default.
• W2896045114 countsByYear W28960451142022 @default.
• W2896045114 countsByYear W28960451142023 @default.
• W2896045114 crossrefType "journal-article" @default.
• W2896045114 hasAuthorship W2896045114A5018088664 @default.
• W2896045114 hasAuthorship W2896045114A5021197154 @default.
• W2896045114 hasAuthorship W2896045114A5042356327 @default.
• W2896045114 hasBestOaLocation W28960451141 @default.
• W2896045114 hasConcept C111684460 @default.
• W2896045114 hasConcept C142724271 @default.
• W2896045114 hasConcept C15755913 @default.
• W2896045114 hasConcept C159654299 @default.
• W2896045114 hasConcept C169760540 @default.
• W2896045114 hasConcept C19106626 @default.
• W2896045114 hasConcept C203014093 @default.
• W2896045114 hasConcept C2776985911 @default.
• W2896045114 hasConcept C2777542381 @default.
• W2896045114 hasConcept C2778609137 @default.
• W2896045114 hasConcept C2781137167 @default.
• W2896045114 hasConcept C529278444 @default.
• W2896045114 hasConcept C71924100 @default.
• W2896045114 hasConcept C79196540 @default.
• W2896045114 hasConcept C86803240 @default.
• W2896045114 hasConceptScore W2896045114C111684460 @default.
• W2896045114 hasConceptScore W2896045114C142724271 @default.
• W2896045114 hasConceptScore W2896045114C15755913 @default.
• W2896045114 hasConceptScore W2896045114C159654299 @default.
• W2896045114 hasConceptScore W2896045114C169760540 @default.
• W2896045114 hasConceptScore W2896045114C19106626 @default.
• W2896045114 hasConceptScore W2896045114C203014093 @default.
• W2896045114 hasConceptScore W2896045114C2776985911 @default.
• W2896045114 hasConceptScore W2896045114C2777542381 @default.
• W2896045114 hasConceptScore W2896045114C2778609137 @default.
• W2896045114 hasConceptScore W2896045114C2781137167 @default.
• W2896045114 hasConceptScore W2896045114C529278444 @default.
• W2896045114 hasConceptScore W2896045114C71924100 @default.
• W2896045114 hasConceptScore W2896045114C79196540 @default.
• W2896045114 hasConceptScore W2896045114C86803240 @default.
• W2896045114 hasFunder F4320310242 @default.
• W2896045114 hasFunder F4320332161 @default.
• W2896045114 hasIssue "1" @default.

• next