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• W2896046465 abstract "Previous evidence showed abnormal posterior sources of resting state delta (<4Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a “disconnection cortical syndrome”, in comparison with PDD and DLB. Resting state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Nold) participants. eLORETA freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. Area under Receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values > 0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD vs. Nold individuals (0.84) than for DLB vs. Nold (0.78) and PDD vs. Nold (0.75). Functional cortical connectivity” markers in delta and alpha sources suggest a more compromised neurophysiological reserve in Alzheimer's than Lewy body dementia, at both group and individual levels." @default.
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• W2896046465 date "2018-07-01" @default.
• W2896046465 modified "2023-10-16" @default.
• W2896046465 title "O1‐10‐04: ABNORMALITIES OF RESTING STATE FUNCTIONAL CORTICAL CONNECTIVITY IN PATIENTS WITH DEMENTIA DUE TO ALZHEIMER'S AND LEWY BODY DISEASES: AN EEG STUDY" @default.
• W2896046465 doi "https://doi.org/10.1016/j.jalz.2018.06.2387" @default.
• W2896046465 hasPublicationYear "2018" @default.
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