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- W2896047537 abstract "Hearing loss (HL) in midlife (ages 45-65) may be associated with long-term neurodegeneration of temporal lobe structures, which show early pathology in Alzheimer's disease. Hearing loss (HL), as measured by the pure tone average (PTA) between 1990 and 1994, was investigated as a predictor of MRI-based temporal volume loss, measured from 2008 to 2015, in 194 Baltimore Longitudinal Study of Aging participants (mean age of 54.5 years with mean follow-up time of 19.3 years). Linear mixed effects models were used to examine the association of PTA measured in right and left ears and change in right and left temporal lobe structures, adjusting for baseline demographic characteristics (age, sex, cognitive status, education), intracranial volume, and vascular burden. A 10-dB increase in PTA from the right ear was associated with bilateral volumetric declines in hippocampi, entorhinal cortex, and parahippocampal gyrus, as well as ventricular enlargement (Table 1). A 10-dB increase of PTA in the right ear also was associated with accelerated volumetric declines in the right middle temporal gyrus (β=-0.0020, Standard Error, [SE]=0.008, p=0.011), right temporal pole (β=-0.012, SE=0.006, p=0.028), and the left fusiform gyrus (β=-0.011, SE=0.005, p=0.025). In contrast, a 10-dB increase in PTA from the left ear showed significant associations only with right (β=0.1186, p=0.0006) and left (β=0.1292, p=0.0004) ventricular enlargement (Table 1). Lateralized differences in how hearing may affect the brain were found, which is consistent with the possibility of right ear advantage. The right ear advantage postulates that contralateral pathways are strongest for speech and language processing, which occurs predominantly in the left hemisphere. Those with greater hearing loss in the right ear may have diminished right ear dominance and greater bilateral and unilateral atrophy over time in temporal lobe structures." @default.
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- W2896047537 date "2018-07-01" @default.
- W2896047537 modified "2023-10-16" @default.
- W2896047537 title "P2‐410: RIGHT EAR ADVANTAGE: ASSOCIATION OF LATERALITY OF PERIPHERAL HEARING LOSS WITH TEMPORAL LOBE NEURODEGENERATION" @default.
- W2896047537 doi "https://doi.org/10.1016/j.jalz.2018.06.1102" @default.
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