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- W2896054231 endingPage "e0206110" @default.
- W2896054231 startingPage "e0206110" @default.
- W2896054231 abstract "Legionella spp. are the cause of a severe bacterial pneumonia known as Legionnaires' disease (LD). In some cases, current genetic subtyping methods cannot resolve LD outbreaks caused by common, potentially endemic L. pneumophila (Lp) sequence types (ST), which complicates laboratory investigations and environmental source attribution. In the United States (US), ST1 is the most prevalent clinical and environmental Lp sequence type. In order to characterize the ST1 population, we sequenced 289 outbreak and non-outbreak associated clinical and environmental ST1 and ST1-variant Lp strains from the US and, together with international isolate sequences, explored their genetic and geographic diversity. The ST1 population was highly conserved at the nucleotide level; 98% of core nucleotide positions were invariant and environmental isolates unassociated with human disease (n = 99) contained ~65% more nucleotide diversity compared to clinical-sporadic (n = 139) or outbreak-associated (n = 28) ST1 subgroups. The accessory pangenome of environmental isolates was also ~30-60% larger than other subgroups and was enriched for transposition and conjugative transfer-associated elements. Up to ~10% of US ST1 genetic variation could be explained by geographic origin, but considerable genetic conservation existed among strains isolated from geographically distant states and from different decades. These findings provide new insight into the ST1 population structure and establish a foundation for interpreting genetic relationships among ST1 strains; these data may also inform future analyses for improved outbreak investigations." @default.
- W2896054231 created "2018-10-26" @default.
- W2896054231 creator A5013171189 @default.
- W2896054231 creator A5028692982 @default.
- W2896054231 creator A5040905123 @default.
- W2896054231 creator A5045947646 @default.
- W2896054231 creator A5053761525 @default.
- W2896054231 creator A5054815305 @default.
- W2896054231 date "2018-10-18" @default.
- W2896054231 modified "2023-10-12" @default.
- W2896054231 title "Genomic heterogeneity differentiates clinical and environmental subgroups of Legionella pneumophila sequence type 1" @default.
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