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- W2896055889 abstract "Current single-cell RNA-seq approaches are hindered by preamplification bias, loss of strand of origin information, and the inability to observe small-RNA and mRNA dual transcriptomes. Here, we introduce a single-cell holo-transcriptome sequencing (Holo-Seq) that overcomes all three hurdles. Holo-Seq has the same quantitative accuracy and uniform coverage with a complete strand of origin information as bulk RNA-seq. Most importantly, Holo-Seq can simultaneously observe small RNAs and mRNAs in a single cell. Furthermore, we acquire small RNA and mRNA dual transcriptomes of 32 human hepatocellular carcinoma single cells, which display the genome-wide super-enhancer activity and hepatic neoplasm kinetics of these cells." @default.
- W2896055889 created "2018-10-26" @default.
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- W2896055889 date "2018-10-17" @default.
- W2896055889 modified "2023-09-29" @default.
- W2896055889 title "Holo-Seq: single-cell sequencing of holo-transcriptome" @default.
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- W2896055889 doi "https://doi.org/10.1186/s13059-018-1553-7" @default.
- W2896055889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6193298" @default.
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