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• W2896058999 abstract "Genetic variants are currently a major component of system-wide investigations into biological function or disease. Approaches to select variants (often out of thousands of candidates) that are responsible for a particular phenomenon have many clinical applications and can help illuminate differences between individuals. Selecting meaningful variants is greatly aided by integration with information about molecular mechanism, whether known from protein structures or interactions or biological pathways. In this review we discuss the nature of genetic variants, and recent studies highlighting what is currently known about the relationship between genetic variation, biomolecular function, and disease." @default.
• W2896058999 created "2018-10-26" @default.
• W2896058999 creator A5045103162 @default.
• W2896058999 creator A5069978192 @default.
• W2896058999 date "2018-10-12" @default.
• W2896058999 modified "2023-10-14" @default.
• W2896058999 title "Studying how genetic variants affect mechanism in biological systems" @default.
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• W2896058999 doi "https://doi.org/10.1042/ebc20180021" @default.
• W2896058999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315099" @default.
• W2896058999 hasPublicationYear "2018" @default.
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