Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896060856> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2896060856 abstract "Background: Orthosiphon stamineus is a traditional medicinal plant in Southeast Asia countries with various well-known pharmacological activities such as antidiabetic, diuretics and antitumor activities. Transketolase is one of the proteins identified in the leaves of the plant and transketolase is believed able to lower blood sugar level in human through non-pancreatic mechanism. In order to understand the protein behavioral properties, 3D model of transketolase and analysis of protein structure are of obvious interest. Methods: In the present study, 3D model of transketolase was constructed and its atomic characteristics revealed. Besides, molecular dynamic simulation of the protein at 310 K and 368 K deciphered transketolase may be a thermophilic protein as the structure does not distort even at elevated temperature. This study also used the protein at 310 K and 368 K resimulated back at 310 K environment. Results: The results revealed that the protein is stable at all condition which suggest that it has high capacity to adapt at different environment not only at high temperature but also from high temperature condition to low temperature where the structure remains unchanged while retaining protein function. Conclusion: The thermostability properties of transketolase is beneficial for pharmaceutical industries as most of the drug making processes are at high temperature condition." @default.
- W2896060856 created "2018-10-26" @default.
- W2896060856 creator A5031965667 @default.
- W2896060856 creator A5050290161 @default.
- W2896060856 creator A5070607734 @default.
- W2896060856 date "2019-07-01" @default.
- W2896060856 modified "2023-10-12" @default.
- W2896060856 title "Molecular Modeling and Simulation of Transketolase from Orthosiphon stamineus" @default.
- W2896060856 cites W1970058440 @default.
- W2896060856 cites W1971421850 @default.
- W2896060856 cites W1991411878 @default.
- W2896060856 cites W1995816895 @default.
- W2896060856 cites W1998902553 @default.
- W2896060856 cites W2016784806 @default.
- W2896060856 cites W2018154003 @default.
- W2896060856 cites W2018895743 @default.
- W2896060856 cites W2020585948 @default.
- W2896060856 cites W2031180668 @default.
- W2896060856 cites W2047053631 @default.
- W2896060856 cites W2048862832 @default.
- W2896060856 cites W2050751548 @default.
- W2896060856 cites W2056127869 @default.
- W2896060856 cites W2056774951 @default.
- W2896060856 cites W2063158400 @default.
- W2896060856 cites W2066779642 @default.
- W2896060856 cites W2068678697 @default.
- W2896060856 cites W2071486470 @default.
- W2896060856 cites W2104293716 @default.
- W2896060856 cites W2176262076 @default.
- W2896060856 cites W2296026787 @default.
- W2896060856 cites W2411337970 @default.
- W2896060856 cites W2584676873 @default.
- W2896060856 cites W30218150 @default.
- W2896060856 cites W36298969 @default.
- W2896060856 cites W4244736178 @default.
- W2896060856 doi "https://doi.org/10.2174/1573409914666181022141753" @default.
- W2896060856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30345923" @default.
- W2896060856 hasPublicationYear "2019" @default.
- W2896060856 type Work @default.
- W2896060856 sameAs 2896060856 @default.
- W2896060856 citedByCount "0" @default.
- W2896060856 crossrefType "journal-article" @default.
- W2896060856 hasAuthorship W2896060856A5031965667 @default.
- W2896060856 hasAuthorship W2896060856A5050290161 @default.
- W2896060856 hasAuthorship W2896060856A5070607734 @default.
- W2896060856 hasConcept C103432212 @default.
- W2896060856 hasConcept C14036430 @default.
- W2896060856 hasConcept C181199279 @default.
- W2896060856 hasConcept C185592680 @default.
- W2896060856 hasConcept C2781216036 @default.
- W2896060856 hasConcept C55493867 @default.
- W2896060856 hasConcept C86803240 @default.
- W2896060856 hasConcept C95444343 @default.
- W2896060856 hasConceptScore W2896060856C103432212 @default.
- W2896060856 hasConceptScore W2896060856C14036430 @default.
- W2896060856 hasConceptScore W2896060856C181199279 @default.
- W2896060856 hasConceptScore W2896060856C185592680 @default.
- W2896060856 hasConceptScore W2896060856C2781216036 @default.
- W2896060856 hasConceptScore W2896060856C55493867 @default.
- W2896060856 hasConceptScore W2896060856C86803240 @default.
- W2896060856 hasConceptScore W2896060856C95444343 @default.
- W2896060856 hasFunder F4320323300 @default.
- W2896060856 hasLocation W28960608561 @default.
- W2896060856 hasLocation W28960608562 @default.
- W2896060856 hasOpenAccess W2896060856 @default.
- W2896060856 hasPrimaryLocation W28960608561 @default.
- W2896060856 hasRelatedWork W2040203327 @default.
- W2896060856 hasRelatedWork W2094336165 @default.
- W2896060856 hasRelatedWork W2305191188 @default.
- W2896060856 hasRelatedWork W2316634517 @default.
- W2896060856 hasRelatedWork W2373154855 @default.
- W2896060856 hasRelatedWork W2418340982 @default.
- W2896060856 hasRelatedWork W2464232842 @default.
- W2896060856 hasRelatedWork W2748952813 @default.
- W2896060856 hasRelatedWork W2896060856 @default.
- W2896060856 hasRelatedWork W2899084033 @default.
- W2896060856 isParatext "false" @default.
- W2896060856 isRetracted "false" @default.
- W2896060856 magId "2896060856" @default.
- W2896060856 workType "article" @default.