FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896069187> ?p ?o ?g. }

• W2896069187 abstract "Nowadays, hybrid drugs have gained a significant role in the treatment of different health problems. Most of the hybrid molecules with different heterocyclic moieties were proved to be potent anti-tumor agents in cancer chemotherapy. Hence, the present study is aimed at the evaluation of in vitro anticancer activity of novel hybrid molecules (pyrazolyl benzoxazole conjugates) and to investigate their anticancer activity by molecular docking studies. Designed, synthesized and characterized the novel pyrazolyl benzoxazole conjugates. Anticancer activity of these compounds was determined by SRB assay. Then molecular docking studies were carried out against proto-oncogene tyrosine-protein kinase (ATP-Src, PDB: 2BDF), a putative target for cancer. All the synthesized compound derivatives were evaluated against MCF-7, KB, Hop62 and A549 cancer cell lines. Compounds 9b and 9c exhibited excellent anticancer activities with GI50 values of <0.1 µM against MCF-7 and A549 cell lines. Compound 9e exhibited good antitumor activity on MCF-7 and A-549 with GI50 values of 0.12 µM and 0.19 µM respectively. Compound 9g showed better anticancer activity on A-549 cancer cell line with GI50 of 0.34 µM. The two-hybrid molecules 9b and 9c are found to be comparably potent with the standard drug doxorubicin and may act as drug lead compounds in medicinal chemistry aspect. The present docking investigation proved that having benzoxazole of compound 9c at the position of benzofuran of reference compound (N-acetyl pyrazoline derivative) might be valid for contributing to anti-cancer activity." @default.
• W2896069187 created "2018-10-26" @default.
• W2896069187 creator A5005265314 @default.
• W2896069187 creator A5014373098 @default.
• W2896069187 creator A5043831977 @default.
• W2896069187 creator A5067198046 @default.
• W2896069187 date "2019-06-18" @default.
• W2896069187 modified "2023-09-24" @default.
• W2896069187 title "Novel Pyrazolyl Benzoxazole Conjugates: Design, Synthesis, Molecular Docking Studies and in vitro Anticancer Activities" @default.
• W2896069187 cites W1229371060 @default.
• W2896069187 cites W1964391435 @default.
• W2896069187 cites W1970357728 @default.
• W2896069187 cites W1970840131 @default.
• W2896069187 cites W1977857211 @default.
• W2896069187 cites W1982183474 @default.
• W2896069187 cites W1985588649 @default.
• W2896069187 cites W2005296591 @default.
• W2896069187 cites W2015886942 @default.
• W2896069187 cites W2017106207 @default.
• W2896069187 cites W2022094603 @default.
• W2896069187 cites W2026860218 @default.
• W2896069187 cites W2028877284 @default.
• W2896069187 cites W2031880498 @default.
• W2896069187 cites W2038056960 @default.
• W2896069187 cites W2041094567 @default.
• W2896069187 cites W2043569527 @default.
• W2896069187 cites W2063443576 @default.
• W2896069187 cites W2064229617 @default.
• W2896069187 cites W2081673273 @default.
• W2896069187 cites W2094974725 @default.
• W2896069187 cites W2108987359 @default.
• W2896069187 cites W2109687588 @default.
• W2896069187 cites W2109689528 @default.
• W2896069187 cites W2129707387 @default.
• W2896069187 cites W2145922362 @default.
• W2896069187 cites W2213475492 @default.
• W2896069187 cites W2315525893 @default.
• W2896069187 cites W2331226693 @default.
• W2896069187 cites W2464735074 @default.
• W2896069187 cites W2567868275 @default.
• W2896069187 cites W2754383668 @default.
• W2896069187 cites W2759470318 @default.
• W2896069187 cites W2778752945 @default.
• W2896069187 cites W2799503617 @default.
• W2896069187 cites W2951225605 @default.
• W2896069187 cites W337357350 @default.
• W2896069187 doi "https://doi.org/10.2174/1570178615666181022141919" @default.
• W2896069187 hasPublicationYear "2019" @default.
• W2896069187 type Work @default.
• W2896069187 sameAs 2896069187 @default.
• W2896069187 citedByCount "2" @default.
• W2896069187 countsByYear W28960691872020 @default.
• W2896069187 countsByYear W28960691872022 @default.
• W2896069187 crossrefType "journal-article" @default.
• W2896069187 hasAuthorship W2896069187A5005265314 @default.
• W2896069187 hasAuthorship W2896069187A5014373098 @default.
• W2896069187 hasAuthorship W2896069187A5043831977 @default.
• W2896069187 hasAuthorship W2896069187A5067198046 @default.
• W2896069187 hasConcept C134306372 @default.
• W2896069187 hasConcept C159110408 @default.
• W2896069187 hasConcept C178790620 @default.
• W2896069187 hasConcept C185592680 @default.
• W2896069187 hasConcept C197336794 @default.
• W2896069187 hasConcept C202751555 @default.
• W2896069187 hasConcept C21951064 @default.
• W2896069187 hasConcept C2776694085 @default.
• W2896069187 hasConcept C2778047396 @default.
• W2896069187 hasConcept C2781303535 @default.
• W2896069187 hasConcept C33923547 @default.
• W2896069187 hasConcept C41685203 @default.
• W2896069187 hasConcept C54355233 @default.
• W2896069187 hasConcept C55493867 @default.
• W2896069187 hasConcept C65556437 @default.
• W2896069187 hasConcept C71240020 @default.
• W2896069187 hasConcept C71924100 @default.
• W2896069187 hasConcept C81885089 @default.
• W2896069187 hasConcept C86803240 @default.
• W2896069187 hasConceptScore W2896069187C134306372 @default.
• W2896069187 hasConceptScore W2896069187C159110408 @default.
• W2896069187 hasConceptScore W2896069187C178790620 @default.
• W2896069187 hasConceptScore W2896069187C185592680 @default.
• W2896069187 hasConceptScore W2896069187C197336794 @default.
• W2896069187 hasConceptScore W2896069187C202751555 @default.
• W2896069187 hasConceptScore W2896069187C21951064 @default.
• W2896069187 hasConceptScore W2896069187C2776694085 @default.
• W2896069187 hasConceptScore W2896069187C2778047396 @default.
• W2896069187 hasConceptScore W2896069187C2781303535 @default.
• W2896069187 hasConceptScore W2896069187C33923547 @default.
• W2896069187 hasConceptScore W2896069187C41685203 @default.
• W2896069187 hasConceptScore W2896069187C54355233 @default.
• W2896069187 hasConceptScore W2896069187C55493867 @default.
• W2896069187 hasConceptScore W2896069187C65556437 @default.
• W2896069187 hasConceptScore W2896069187C71240020 @default.
• W2896069187 hasConceptScore W2896069187C71924100 @default.
• W2896069187 hasConceptScore W2896069187C81885089 @default.
• W2896069187 hasConceptScore W2896069187C86803240 @default.
• W2896069187 hasLocation W28960691871 @default.
• W2896069187 hasOpenAccess W2896069187 @default.
• W2896069187 hasPrimaryLocation W28960691871 @default.
• W2896069187 hasRelatedWork W1966121224 @default.

• next