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- W2896069250 endingPage "2854" @default.
- W2896069250 startingPage "2838" @default.
- W2896069250 abstract "Introns are removed by the spliceosome, a large macromolecular complex composed of five ribonucleoprotein subcomplexes (U snRNPs). The U1 snRNP, which binds to 5' splice sites, plays an essential role in early steps of the splicing reaction. Here, we show that Arabidopsis thaliana LETHAL UNLESS CBC7 (LUC7) proteins, which are encoded by a three-member gene family in Arabidopsis, are important for plant development and stress resistance. We show that LUC7 is a U1 snRNP accessory protein by RNA immunoprecipitation experiments and LUC7 protein complex purifications. Transcriptome analyses revealed that LUC7 proteins are not only important for constitutive splicing, but also affect hundreds of alternative splicing events. Interestingly, LUC7 proteins specifically promote splicing of a subset of terminal introns. Splicing of LUC7-dependent introns is a prerequisite for nuclear export, and some splicing events are modulated by stress in a LUC7-dependent manner. Taken together, our results highlight the importance of the U1 snRNP component LUC7 in splicing regulation and suggest a previously unrecognized role of a U1 snRNP accessory factor in terminal intron splicing." @default.
- W2896069250 created "2018-10-26" @default.
- W2896069250 creator A5008117650 @default.
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- W2896069250 creator A5025945746 @default.
- W2896069250 creator A5027805217 @default.
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- W2896069250 creator A5085238149 @default.
- W2896069250 creator A5088252425 @default.
- W2896069250 creator A5091044256 @default.
- W2896069250 date "2018-10-11" @default.
- W2896069250 modified "2023-10-02" @default.
- W2896069250 title "The U1 snRNP Subunit LUC7 Modulates Plant Development and Stress Responses via Regulation of Alternative Splicing" @default.
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