FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896069795> ?p ?o ?g. }

• W2896069795 endingPage "35288" @default.
• W2896069795 startingPage "35280" @default.
• W2896069795 abstract "Single-stranded DNA-binding protein (SSB) is essential for all DNA-dependent cellular processes. The mechanism through which PriA helicase, an initiator protein in the DNA replication restart process, is stimulated by SSB in Escherichia coli (Ec) has been established. Nevertheless, whether or not PriA stimulated by SSB is conserved among Gram-negative bacteria remains unclear, and the SSB specificity for the stimulation effect on PriA is unknown. In this study, three similar SSBs from Klebsiella pneumoniae (KpSSB), Salmonella enterica (StSSB), and Pseudomonas aeruginosa (PaSSB) were used to analyze the stimulation effect. Two chimeric proteins, namely, KpSSBn-PaSSBc and KpSSBn-StSSBc, were also used. KpSSB, StSSB, and KpSSBn-StSSBc can stimulate KpPriA activity, but PaSSB and KpSSBn-PaSSBc cannot. The crystal structure of PaSSB solved at 2.04 A resolution (PDB entry 5YUO) reveals the classic OB fold structure, similar to that of EcSSB. Comparison of SSBs through sequence analysis showed that the typical glycine-rich flexible region in PaSSB contains very few glycine residues. Through analyses of protein chimeragenesis, structure–sequence, and ATPase stimulation effects, we concluded that the inherent difference in the glycine-rich flexible region among SSB species is a determinant of PriA stimulation. Further research can directly focus on determining the type of glycine-rich hinge that can stimulate PriA and the reason why bacterial SSBs need to evolve different C-terminal domains during evolution." @default.
• W2896069795 created "2018-10-26" @default.
• W2896069795 creator A5029550528 @default.
• W2896069795 creator A5063532752 @default.
• W2896069795 date "2018-10-10" @default.
• W2896069795 modified "2023-09-27" @default.
• W2896069795 title "The glycine-rich flexible region in SSB is crucial for PriA stimulation." @default.
• W2896069795 cites W1539796472 @default.
• W2896069795 cites W1806123628 @default.
• W2896069795 cites W1972269311 @default.
• W2896069795 cites W1994279104 @default.
• W2896069795 cites W2006746798 @default.
• W2896069795 cites W2007638964 @default.
• W2896069795 cites W2017393660 @default.
• W2896069795 cites W2017713846 @default.
• W2896069795 cites W2017904568 @default.
• W2896069795 cites W2020164169 @default.
• W2896069795 cites W2028941521 @default.
• W2896069795 cites W2046298637 @default.
• W2896069795 cites W2066638568 @default.
• W2896069795 cites W2069663555 @default.
• W2896069795 cites W2083344047 @default.
• W2896069795 cites W2086705273 @default.
• W2896069795 cites W2086902365 @default.
• W2896069795 cites W2089545337 @default.
• W2896069795 cites W2098969010 @default.
• W2896069795 cites W2131737890 @default.
• W2896069795 cites W2132860946 @default.
• W2896069795 cites W2144081223 @default.
• W2896069795 cites W2152080670 @default.
• W2896069795 cites W2163341755 @default.
• W2896069795 cites W2433647462 @default.
• W2896069795 cites W2461326589 @default.
• W2896069795 cites W2512758629 @default.
• W2896069795 cites W2550762644 @default.
• W2896069795 cites W2574055941 @default.
• W2896069795 cites W2580692595 @default.
• W2896069795 cites W2740373546 @default.
• W2896069795 cites W2771417816 @default.
• W2896069795 cites W2792741532 @default.
• W2896069795 cites W2794497310 @default.
• W2896069795 cites W2885512861 @default.
• W2896069795 doi "https://doi.org/10.2210/pdb5yuo/pdb" @default.
• W2896069795 hasPublicationYear "2018" @default.
• W2896069795 type Work @default.
• W2896069795 sameAs 2896069795 @default.
• W2896069795 citedByCount "1" @default.
• W2896069795 countsByYear W28960697952019 @default.
• W2896069795 crossrefType "component" @default.
• W2896069795 hasAuthorship W2896069795A5029550528 @default.
• W2896069795 hasAuthorship W2896069795A5063532752 @default.
• W2896069795 hasConcept C104317684 @default.
• W2896069795 hasConcept C161223559 @default.
• W2896069795 hasConcept C169760540 @default.
• W2896069795 hasConcept C181199279 @default.
• W2896069795 hasConcept C185592680 @default.
• W2896069795 hasConcept C23265538 @default.
• W2896069795 hasConcept C24998067 @default.
• W2896069795 hasConcept C2777058267 @default.
• W2896069795 hasConcept C2777756961 @default.
• W2896069795 hasConcept C2779607309 @default.
• W2896069795 hasConcept C515207424 @default.
• W2896069795 hasConcept C523546767 @default.
• W2896069795 hasConcept C54355233 @default.
• W2896069795 hasConcept C547475151 @default.
• W2896069795 hasConcept C552990157 @default.
• W2896069795 hasConcept C55493867 @default.
• W2896069795 hasConcept C65556437 @default.
• W2896069795 hasConcept C67705224 @default.
• W2896069795 hasConcept C86803240 @default.
• W2896069795 hasConcept C95444343 @default.
• W2896069795 hasConceptScore W2896069795C104317684 @default.
• W2896069795 hasConceptScore W2896069795C161223559 @default.
• W2896069795 hasConceptScore W2896069795C169760540 @default.
• W2896069795 hasConceptScore W2896069795C181199279 @default.
• W2896069795 hasConceptScore W2896069795C185592680 @default.
• W2896069795 hasConceptScore W2896069795C23265538 @default.
• W2896069795 hasConceptScore W2896069795C24998067 @default.
• W2896069795 hasConceptScore W2896069795C2777058267 @default.
• W2896069795 hasConceptScore W2896069795C2777756961 @default.
• W2896069795 hasConceptScore W2896069795C2779607309 @default.
• W2896069795 hasConceptScore W2896069795C515207424 @default.
• W2896069795 hasConceptScore W2896069795C523546767 @default.
• W2896069795 hasConceptScore W2896069795C54355233 @default.
• W2896069795 hasConceptScore W2896069795C547475151 @default.
• W2896069795 hasConceptScore W2896069795C552990157 @default.
• W2896069795 hasConceptScore W2896069795C55493867 @default.
• W2896069795 hasConceptScore W2896069795C65556437 @default.
• W2896069795 hasConceptScore W2896069795C67705224 @default.
• W2896069795 hasConceptScore W2896069795C86803240 @default.
• W2896069795 hasConceptScore W2896069795C95444343 @default.
• W2896069795 hasIssue "61" @default.
• W2896069795 hasLocation W28960697951 @default.
• W2896069795 hasOpenAccess W2896069795 @default.
• W2896069795 hasPrimaryLocation W28960697951 @default.
• W2896069795 hasRelatedWork W1964345341 @default.
• W2896069795 hasRelatedWork W2014624113 @default.
• W2896069795 hasRelatedWork W2034521979 @default.

• next