Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896070253> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2896070253 abstract "Isavuconazole, a triazole antifungal, is an inhibitor of cytochrome P450 3A4, which also metabolizes tacrolimus and sirolimus. In previous studies, isavuconazole administration increased tacrolimus and sirolimus area under the curve values by 2.3-fold and 1.8-fold, respectively, in healthy adults and tacrolimus concentration/dose (C/D) ratio by 1.3-fold in solid organ transplant patients. We aimed to determine the magnitude of effect of isavuconazole administration on tacrolimus and sirolimus C/D ratios in allogeneic hematopoietic stem cell transplant (alloHSCT) patients.A retrospective, single-center, single-arm study in adult alloHSCT patients who received at least 10 days of combination therapy with isavuconazole and tacrolimus and/or sirolimus as inpatients or outpatients was conducted. Tacrolimus and sirolimus trough serum concentrations were measured up to twice weekly for up to 4 weeks.Twenty-two patients receiving tacrolimus and twenty patients receiving sirolimus met the inclusion criteria. The mean C/D ratio increased from baseline by 1.42-fold for tacrolimus during week 1 (P = 0.002) and up to 1.56-fold for sirolimus during week 2 (P = 0.02). For the remaining timepoints, tacrolimus and sirolimus C/D ratios were not statistically significantly different from baseline.In alloHSCT patients, modest increases in tacrolimus and sirolimus C/D ratios from baseline were observed within the first 2 weeks after initiation of isavuconazole." @default.
- W2896070253 created "2018-10-26" @default.
- W2896070253 creator A5007260018 @default.
- W2896070253 creator A5032627590 @default.
- W2896070253 creator A5039725610 @default.
- W2896070253 creator A5066824581 @default.
- W2896070253 creator A5086494836 @default.
- W2896070253 date "2018-10-23" @default.
- W2896070253 modified "2023-09-30" @default.
- W2896070253 title "Effect of isavuconazole on tacrolimus and sirolimus serum concentrations in allogeneic hematopoietic stem cell transplant patients: A drug-drug interaction study" @default.
- W2896070253 cites W1436442583 @default.
- W2896070253 cites W1840330332 @default.
- W2896070253 cites W1895193516 @default.
- W2896070253 cites W2018002561 @default.
- W2896070253 cites W2072639136 @default.
- W2896070253 cites W2084830679 @default.
- W2896070253 cites W2115289875 @default.
- W2896070253 cites W2119962983 @default.
- W2896070253 cites W2146064240 @default.
- W2896070253 cites W2487631607 @default.
- W2896070253 cites W2732950461 @default.
- W2896070253 cites W2754519822 @default.
- W2896070253 cites W2762058653 @default.
- W2896070253 cites W2884340570 @default.
- W2896070253 doi "https://doi.org/10.1111/tid.13007" @default.
- W2896070253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30295407" @default.
- W2896070253 hasPublicationYear "2018" @default.
- W2896070253 type Work @default.
- W2896070253 sameAs 2896070253 @default.
- W2896070253 citedByCount "17" @default.
- W2896070253 countsByYear W28960702532019 @default.
- W2896070253 countsByYear W28960702532020 @default.
- W2896070253 countsByYear W28960702532021 @default.
- W2896070253 countsByYear W28960702532022 @default.
- W2896070253 countsByYear W28960702532023 @default.
- W2896070253 crossrefType "journal-article" @default.
- W2896070253 hasAuthorship W2896070253A5007260018 @default.
- W2896070253 hasAuthorship W2896070253A5032627590 @default.
- W2896070253 hasAuthorship W2896070253A5039725610 @default.
- W2896070253 hasAuthorship W2896070253A5066824581 @default.
- W2896070253 hasAuthorship W2896070253A5086494836 @default.
- W2896070253 hasBestOaLocation W28960702531 @default.
- W2896070253 hasConcept C112705442 @default.
- W2896070253 hasConcept C126322002 @default.
- W2896070253 hasConcept C126894567 @default.
- W2896070253 hasConcept C128057223 @default.
- W2896070253 hasConcept C185592680 @default.
- W2896070253 hasConcept C2777408962 @default.
- W2896070253 hasConcept C2777921159 @default.
- W2896070253 hasConcept C2780272996 @default.
- W2896070253 hasConcept C2781363766 @default.
- W2896070253 hasConcept C2909675724 @default.
- W2896070253 hasConcept C2911091166 @default.
- W2896070253 hasConcept C3019249092 @default.
- W2896070253 hasConcept C31785415 @default.
- W2896070253 hasConcept C501593827 @default.
- W2896070253 hasConcept C55493867 @default.
- W2896070253 hasConcept C71924100 @default.
- W2896070253 hasConcept C90924648 @default.
- W2896070253 hasConcept C98274493 @default.
- W2896070253 hasConceptScore W2896070253C112705442 @default.
- W2896070253 hasConceptScore W2896070253C126322002 @default.
- W2896070253 hasConceptScore W2896070253C126894567 @default.
- W2896070253 hasConceptScore W2896070253C128057223 @default.
- W2896070253 hasConceptScore W2896070253C185592680 @default.
- W2896070253 hasConceptScore W2896070253C2777408962 @default.
- W2896070253 hasConceptScore W2896070253C2777921159 @default.
- W2896070253 hasConceptScore W2896070253C2780272996 @default.
- W2896070253 hasConceptScore W2896070253C2781363766 @default.
- W2896070253 hasConceptScore W2896070253C2909675724 @default.
- W2896070253 hasConceptScore W2896070253C2911091166 @default.
- W2896070253 hasConceptScore W2896070253C3019249092 @default.
- W2896070253 hasConceptScore W2896070253C31785415 @default.
- W2896070253 hasConceptScore W2896070253C501593827 @default.
- W2896070253 hasConceptScore W2896070253C55493867 @default.
- W2896070253 hasConceptScore W2896070253C71924100 @default.
- W2896070253 hasConceptScore W2896070253C90924648 @default.
- W2896070253 hasConceptScore W2896070253C98274493 @default.
- W2896070253 hasIssue "1" @default.
- W2896070253 hasLocation W28960702531 @default.
- W2896070253 hasLocation W28960702532 @default.
- W2896070253 hasOpenAccess W2896070253 @default.
- W2896070253 hasPrimaryLocation W28960702531 @default.
- W2896070253 hasRelatedWork W1966785288 @default.
- W2896070253 hasRelatedWork W1970601178 @default.
- W2896070253 hasRelatedWork W1979796457 @default.
- W2896070253 hasRelatedWork W2011948815 @default.
- W2896070253 hasRelatedWork W2037182741 @default.
- W2896070253 hasRelatedWork W2045521227 @default.
- W2896070253 hasRelatedWork W2084443296 @default.
- W2896070253 hasRelatedWork W2321257908 @default.
- W2896070253 hasRelatedWork W2444456071 @default.
- W2896070253 hasRelatedWork W2896070253 @default.
- W2896070253 hasVolume "21" @default.
- W2896070253 isParatext "false" @default.
- W2896070253 isRetracted "false" @default.
- W2896070253 magId "2896070253" @default.
- W2896070253 workType "article" @default.