FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896070890> ?p ?o ?g. }

• W2896070890 abstract "Impaired cerebrovascular function can lead to cognitive dysfunction and is implicated as a potential mechanism by which vascular stressors (Aβ, saturated fatty acids such as palmitic acid PA or high glucose HG) contribute to dementia. We aim to test the hypothesis that cognitive function score correlates significantly with baseline ex-vivo cerebrovascular function and dilator response to vascular stressors. Methods: Under a Brain Donation Rapid Autopsy Program, leptomeningeal arterioles were isolated from 59 donors (87.4±1.1 years, 13 cognitively normal, 46 with various neuropathologies), cannulated, pressurized and endothelium-dependent dilation (EDD, acetylcholine max 10 -4 M) and smooth muscle dilation (SMD, papaverine or DETA-Nonoate) were measured at baseline and following exposure to Aβ42 (0.5 or 2 μM, n=40), PA 150 μM (n=13) or high glucose 33 mM (n=11). Correlation analyses were performed between cognitive function score (last mini mental state examination MMSE) and baseline and post-exposure arteriole function. Results: There was no correlation between MMSE score and baseline EDD and SMD (Fig. A-B). Exposure of arterioles to Aβ and PA significantly impaired EDD (-29.1±4.6% and -27.6±9.1% vs. baseline, p<0.05) but not HG (-2.7±6.6%). Aβ and PA impaired SMD (-7.4±3 and -7.4±6.7% vs. baseline, p<0.05) but not HG (0.1±4.4%). There was no significant correlation between MMSE score and arteriole EDD and SMD response to Aβ and PA. However, there was significant correlation between MMSE score and arteriole SMD response to HG (Fig. C). Conclusions: Contrary to our hypothesis, there was no correlation between cognitive function score and baseline ex-vivo leptomeningeal arteriole function. There was significant correlation between cognitive function score and SMD response to HG (but not Aβ or PA). The role of cerebrovascular smooth muscle reserve against hyperglycemic insult in the pathophysiology of cognitive dysfunction needs to be further explored." @default.
• W2896070890 created "2018-10-26" @default.
• W2896070890 creator A5033012778 @default.
• W2896070890 creator A5048256532 @default.
• W2896070890 creator A5050607848 @default.
• W2896070890 creator A5072613176 @default.
• W2896070890 creator A5076508749 @default.
• W2896070890 creator A5081140590 @default.
• W2896070890 date "2018-01-22" @default.
• W2896070890 modified "2023-10-02" @default.
• W2896070890 title "Abstract TMP96: Determining the Relationship Between Cognitive Function and ex-vivo Leptomeningeal Arteriole Function: A Study in Rapid Autopsy Brain Donors" @default.
• W2896070890 doi "https://doi.org/10.1161/str.49.suppl_1.tmp96" @default.
• W2896070890 hasPublicationYear "2018" @default.
• W2896070890 type Work @default.
• W2896070890 sameAs 2896070890 @default.
• W2896070890 citedByCount "0" @default.
• W2896070890 crossrefType "journal-article" @default.
• W2896070890 hasAuthorship W2896070890A5033012778 @default.
• W2896070890 hasAuthorship W2896070890A5048256532 @default.
• W2896070890 hasAuthorship W2896070890A5050607848 @default.
• W2896070890 hasAuthorship W2896070890A5072613176 @default.
• W2896070890 hasAuthorship W2896070890A5076508749 @default.
• W2896070890 hasAuthorship W2896070890A5081140590 @default.
• W2896070890 hasConcept C126322002 @default.
• W2896070890 hasConcept C12722491 @default.
• W2896070890 hasConcept C164705383 @default.
• W2896070890 hasConcept C2777032099 @default.
• W2896070890 hasConcept C2779134260 @default.
• W2896070890 hasConcept C2779482390 @default.
• W2896070890 hasConcept C2779483572 @default.
• W2896070890 hasConcept C71924100 @default.
• W2896070890 hasConceptScore W2896070890C126322002 @default.
• W2896070890 hasConceptScore W2896070890C12722491 @default.
• W2896070890 hasConceptScore W2896070890C164705383 @default.
• W2896070890 hasConceptScore W2896070890C2777032099 @default.
• W2896070890 hasConceptScore W2896070890C2779134260 @default.
• W2896070890 hasConceptScore W2896070890C2779482390 @default.
• W2896070890 hasConceptScore W2896070890C2779483572 @default.
• W2896070890 hasConceptScore W2896070890C71924100 @default.
• W2896070890 hasIssue "Suppl_1" @default.
• W2896070890 hasLocation W28960708901 @default.
• W2896070890 hasOpenAccess W2896070890 @default.
• W2896070890 hasPrimaryLocation W28960708901 @default.
• W2896070890 hasRelatedWork W1963656657 @default.
• W2896070890 hasRelatedWork W1971155155 @default.
• W2896070890 hasRelatedWork W1975762558 @default.
• W2896070890 hasRelatedWork W1990015114 @default.
• W2896070890 hasRelatedWork W1990888000 @default.
• W2896070890 hasRelatedWork W2027415925 @default.
• W2896070890 hasRelatedWork W2083351808 @default.
• W2896070890 hasRelatedWork W2434360405 @default.
• W2896070890 hasRelatedWork W3152261600 @default.
• W2896070890 hasRelatedWork W4205630432 @default.
• W2896070890 hasVolume "49" @default.
• W2896070890 isParatext "false" @default.
• W2896070890 isRetracted "false" @default.
• W2896070890 magId "2896070890" @default.
• W2896070890 workType "article" @default.