FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896074232> ?p ?o ?g. }

• W2896074232 endingPage "e598" @default.
• W2896074232 startingPage "e598" @default.
• W2896074232 abstract "AeroForm® (AirXpanders, Inc., Palo Alto, CA) is a carbon dioxide-based, patient-controlled tissue expander that enables patients to undergo more convenient and rapid tissue expansion compared to traditional saline expanders. It was approved by the FDA for use in post-mastectomy reconstruction at the end of 2016, and has been increasingly seen in women requiring post-mastectomy radiation therapy (PMRT). The presence of the AeroForm®, however, presents a dosimetric challenge in the delivery of PMRT given the presence of high density stainless steel within the expander. In this study we explore the ability of the treatment planning system (TPS) to predict dose in the presence of an Aeroform®, and confirm the accuracy of our TPS by performing in vivo dose measurements in a patient receiving PMRT. External beam radiation planning was performed in treatment planning software. A 3D field-in-field treatment plan using an electron-photon match medially to cover the internal mammary nodes was created and calculated using both Acuros XB (AXB) and anisotropic analytical algorithm (AAA). A material override for high density material was incorporated into the AXB algorithm to account for areas of saturation on our planning CT scan due to the expander. In vivo dose measurements were performed using optically stimulated luminescent dosimeters (OSLD, nanoDot™, Landauer) placed at designated points correlating to cold spots seen in the TPS on our patient. We observed significant areas of dose reduction within our target volume using the AXB algorithm in our treatment planning system (TPS). This was not apparent when using AAA. In vivo measurements confirmed our observed loss of target volume coverage lateral to the AeroForm® due to attenuation of the tangent photon beams by the implant device. Loss of target volume coverage medially was less pronounced as this area was covered separately by an electron field in our treatment plan. We observed a 6% difference (170 vs 159.5cGy, prescribed dose 200cGy) between AXB calculated dose with delivered dose. We found that increasing bolus from 0.5 to 1 cm only modestly improved coverage at the skin in our TPS, however did not overcome attenuation by the expander. AXB predicts dose more accurately than AAA in Aeroform® patients due to the presence of both high density stainless steel and air within the expander. The Aeroform® tissue expander, however, significantly attenuates incoming photon tangent beams. The significant cold spots witnessed both medially and laterally to the expander may be overcome with additional boost fields, however, are not resolved with the addition of bolus." @default.
• W2896074232 created "2018-10-26" @default.
• W2896074232 creator A5010095960 @default.
• W2896074232 creator A5020461468 @default.
• W2896074232 creator A5033835581 @default.
• W2896074232 creator A5039892778 @default.
• W2896074232 creator A5051058729 @default.
• W2896074232 creator A5060166159 @default.
• W2896074232 date "2018-11-01" @default.
• W2896074232 modified "2023-10-01" @default.
• W2896074232 title "Air Expander Implant Can Compromise Target Coverage and Dose Homogeneity of Post-Mastectomy Radiation Therapy" @default.
• W2896074232 doi "https://doi.org/10.1016/j.ijrobp.2018.07.1644" @default.
• W2896074232 hasPublicationYear "2018" @default.
• W2896074232 type Work @default.
• W2896074232 sameAs 2896074232 @default.
• W2896074232 citedByCount "0" @default.
• W2896074232 crossrefType "journal-article" @default.
• W2896074232 hasAuthorship W2896074232A5010095960 @default.
• W2896074232 hasAuthorship W2896074232A5020461468 @default.
• W2896074232 hasAuthorship W2896074232A5033835581 @default.
• W2896074232 hasAuthorship W2896074232A5039892778 @default.
• W2896074232 hasAuthorship W2896074232A5051058729 @default.
• W2896074232 hasAuthorship W2896074232A5060166159 @default.
• W2896074232 hasConcept C104293457 @default.
• W2896074232 hasConcept C105636585 @default.
• W2896074232 hasConcept C121608353 @default.
• W2896074232 hasConcept C126322002 @default.
• W2896074232 hasConcept C136229726 @default.
• W2896074232 hasConcept C141071460 @default.
• W2896074232 hasConcept C201645570 @default.
• W2896074232 hasConcept C2777757722 @default.
• W2896074232 hasConcept C2779244869 @default.
• W2896074232 hasConcept C2781411149 @default.
• W2896074232 hasConcept C2989005 @default.
• W2896074232 hasConcept C509974204 @default.
• W2896074232 hasConcept C530470458 @default.
• W2896074232 hasConcept C71924100 @default.
• W2896074232 hasConcept C75088862 @default.
• W2896074232 hasConceptScore W2896074232C104293457 @default.
• W2896074232 hasConceptScore W2896074232C105636585 @default.
• W2896074232 hasConceptScore W2896074232C121608353 @default.
• W2896074232 hasConceptScore W2896074232C126322002 @default.
• W2896074232 hasConceptScore W2896074232C136229726 @default.
• W2896074232 hasConceptScore W2896074232C141071460 @default.
• W2896074232 hasConceptScore W2896074232C201645570 @default.
• W2896074232 hasConceptScore W2896074232C2777757722 @default.
• W2896074232 hasConceptScore W2896074232C2779244869 @default.
• W2896074232 hasConceptScore W2896074232C2781411149 @default.
• W2896074232 hasConceptScore W2896074232C2989005 @default.
• W2896074232 hasConceptScore W2896074232C509974204 @default.
• W2896074232 hasConceptScore W2896074232C530470458 @default.
• W2896074232 hasConceptScore W2896074232C71924100 @default.
• W2896074232 hasConceptScore W2896074232C75088862 @default.
• W2896074232 hasIssue "3" @default.
• W2896074232 hasLocation W28960742321 @default.
• W2896074232 hasOpenAccess W2896074232 @default.
• W2896074232 hasPrimaryLocation W28960742321 @default.
• W2896074232 hasRelatedWork W1963976717 @default.
• W2896074232 hasRelatedWork W1995546375 @default.
• W2896074232 hasRelatedWork W1998384890 @default.
• W2896074232 hasRelatedWork W1998506732 @default.
• W2896074232 hasRelatedWork W2019232551 @default.
• W2896074232 hasRelatedWork W2046366494 @default.
• W2896074232 hasRelatedWork W2339158011 @default.
• W2896074232 hasRelatedWork W2800477359 @default.
• W2896074232 hasRelatedWork W4311090215 @default.
• W2896074232 hasRelatedWork W3119982870 @default.
• W2896074232 hasVolume "102" @default.
• W2896074232 isParatext "false" @default.
• W2896074232 isRetracted "false" @default.
• W2896074232 magId "2896074232" @default.
• W2896074232 workType "article" @default.