FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896075151> ?p ?o ?g. }

• W2896075151 abstract "Therapies under development for AD employ strategies designed to modify disease processes. Early detection of presymptomatic AD-related changes will be important for effective treatment. Current diagnostic methods rely on the occurrence of late AD symptoms including memory impairment and functional decline, and others are invasive, time-consuming and/or expensive. DNA methylation (DNAm) changes in blood have been shown to associate with AD pathophysiology and progression. Our goal was to identify DNAm changes as associated with disease progression within the Alzheimer's disease Neuroimaging Initiative (ADNI) cohort as peripheral biomarkers of prodromal AD and to facilitate novel drug target discovery. Blood-derived DNA samples from cognitively normal (CN), mild cognitive impairment (MCI), and AD participants in ADNI underwent DNAm analysis using the Illumina EPIC array followed by quality control and normalization. Age, sex, education, and cell composition were used as covariates. Blood RNA expression data on a subset of participants were analyzed. Cross-sectional analyses yielded 483, 139, and 299 differentially methylated positions (DMPs) for the AD-CN, AD-MCI, and MCI-CN comparisons including 433, 135, and 269 genes upon annotation with the nearest transcription start sites (TSS), which enriched for neuronal-associated genes (adj.p<0.01) when analyzing for tissue-specific expression using GTEx data. Gene ontology analysis identified neurodevelopment and neurotransmission as the most highly enriched pathways (adj.p<0.05). We found hypermethylation upstream of the BIN1 (Bridging Integrator 1) TSS in MCI and AD relative to CN subjects. Blood RNA expression analysis indicated downregulation of BIN1 expression in AD relative to CN. We also found DNAm changes in other genes associated with neurodegeneration (e.g. BDNF), and in genes associated with neurotransmission and synaptic function (e.g. KCNN2). In addition to replicating previously characterized DNAm changes in AD subjects, our results show DNAm changes in genes associated with neurodevelopment and synaptic function. This is the largest study on DNAm changes across the AD spectrum thus far. Ongoing analysis of longitudinal DNAm changes and their associations with AD biomarker changes (e.g. amyloid and tau burden, atrophy, cognitive performance) will facilitate the identification of early biomarkers of disease progression, provide insight into the mechanisms of AD pathogenesis, and facilitate novel target discovery." @default.
• W2896075151 created "2018-10-26" @default.
• W2896075151 creator A5000415188 @default.
• W2896075151 creator A5013266798 @default.
• W2896075151 creator A5017466920 @default.
• W2896075151 creator A5026257338 @default.
• W2896075151 creator A5027323364 @default.
• W2896075151 creator A5030516885 @default.
• W2896075151 creator A5033942521 @default.
• W2896075151 creator A5036245359 @default.
• W2896075151 creator A5041791625 @default.
• W2896075151 creator A5048034644 @default.
• W2896075151 creator A5052635192 @default.
• W2896075151 creator A5053987349 @default.
• W2896075151 creator A5056848023 @default.
• W2896075151 creator A5069777080 @default.
• W2896075151 creator A5070191350 @default.
• W2896075151 creator A5087319886 @default.
• W2896075151 creator A5091020033 @default.
• W2896075151 date "2018-07-01" @default.
• W2896075151 modified "2023-10-02" @default.
• W2896075151 title "P3‐120: DNA METHYLATION DYNAMICS IN ALZHEIMER'S DISEASE: DEVELOPMENT OF BIOMARKERS AND NOVEL DRUG TARGETS USING ADNI EPIGENETIC DATA" @default.
• W2896075151 doi "https://doi.org/10.1016/j.jalz.2018.06.1477" @default.
• W2896075151 hasPublicationYear "2018" @default.
• W2896075151 type Work @default.
• W2896075151 sameAs 2896075151 @default.
• W2896075151 citedByCount "0" @default.
• W2896075151 crossrefType "journal-article" @default.
• W2896075151 hasAuthorship W2896075151A5000415188 @default.
• W2896075151 hasAuthorship W2896075151A5013266798 @default.
• W2896075151 hasAuthorship W2896075151A5017466920 @default.
• W2896075151 hasAuthorship W2896075151A5026257338 @default.
• W2896075151 hasAuthorship W2896075151A5027323364 @default.
• W2896075151 hasAuthorship W2896075151A5030516885 @default.
• W2896075151 hasAuthorship W2896075151A5033942521 @default.
• W2896075151 hasAuthorship W2896075151A5036245359 @default.
• W2896075151 hasAuthorship W2896075151A5041791625 @default.
• W2896075151 hasAuthorship W2896075151A5048034644 @default.
• W2896075151 hasAuthorship W2896075151A5052635192 @default.
• W2896075151 hasAuthorship W2896075151A5053987349 @default.
• W2896075151 hasAuthorship W2896075151A5056848023 @default.
• W2896075151 hasAuthorship W2896075151A5069777080 @default.
• W2896075151 hasAuthorship W2896075151A5070191350 @default.
• W2896075151 hasAuthorship W2896075151A5087319886 @default.
• W2896075151 hasAuthorship W2896075151A5091020033 @default.
• W2896075151 hasConcept C104317684 @default.
• W2896075151 hasConcept C126322002 @default.
• W2896075151 hasConcept C143998085 @default.
• W2896075151 hasConcept C150194340 @default.
• W2896075151 hasConcept C154253233 @default.
• W2896075151 hasConcept C190727270 @default.
• W2896075151 hasConcept C2775921022 @default.
• W2896075151 hasConcept C2779134260 @default.
• W2896075151 hasConcept C2781197716 @default.
• W2896075151 hasConcept C33288867 @default.
• W2896075151 hasConcept C41091548 @default.
• W2896075151 hasConcept C54355233 @default.
• W2896075151 hasConcept C60644358 @default.
• W2896075151 hasConcept C71924100 @default.
• W2896075151 hasConcept C86803240 @default.
• W2896075151 hasConceptScore W2896075151C104317684 @default.
• W2896075151 hasConceptScore W2896075151C126322002 @default.
• W2896075151 hasConceptScore W2896075151C143998085 @default.
• W2896075151 hasConceptScore W2896075151C150194340 @default.
• W2896075151 hasConceptScore W2896075151C154253233 @default.
• W2896075151 hasConceptScore W2896075151C190727270 @default.
• W2896075151 hasConceptScore W2896075151C2775921022 @default.
• W2896075151 hasConceptScore W2896075151C2779134260 @default.
• W2896075151 hasConceptScore W2896075151C2781197716 @default.
• W2896075151 hasConceptScore W2896075151C33288867 @default.
• W2896075151 hasConceptScore W2896075151C41091548 @default.
• W2896075151 hasConceptScore W2896075151C54355233 @default.
• W2896075151 hasConceptScore W2896075151C60644358 @default.
• W2896075151 hasConceptScore W2896075151C71924100 @default.
• W2896075151 hasConceptScore W2896075151C86803240 @default.
• W2896075151 hasIssue "7S_Part_20" @default.
• W2896075151 hasLocation W28960751511 @default.
• W2896075151 hasOpenAccess W2896075151 @default.
• W2896075151 hasPrimaryLocation W28960751511 @default.
• W2896075151 hasRelatedWork W1698395555 @default.
• W2896075151 hasRelatedWork W2181135448 @default.
• W2896075151 hasRelatedWork W2477521417 @default.
• W2896075151 hasRelatedWork W2980158117 @default.
• W2896075151 hasRelatedWork W3048787436 @default.
• W2896075151 hasRelatedWork W3102631590 @default.
• W2896075151 hasRelatedWork W3110143705 @default.
• W2896075151 hasRelatedWork W4324285197 @default.
• W2896075151 hasRelatedWork W4377115889 @default.
• W2896075151 hasRelatedWork W4379618377 @default.
• W2896075151 hasVolume "14" @default.
• W2896075151 isParatext "false" @default.
• W2896075151 isRetracted "false" @default.
• W2896075151 magId "2896075151" @default.
• W2896075151 workType "article" @default.