Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896075424> ?p ?o ?g. }
- W2896075424 abstract "Abstract Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state. Additionally, roughly 14 − 19% of mature spines have a specialized endoplasmic reticulum called the spine apparatus. How does the shape of a postsynaptic spine and its internal organization affect the spatio-temporal dynamics of short timescale signaling? Answers to this question are central to our understanding the initiation of synaptic transmission, learning, and memory formation. In this work, we investigated the effect of spine and spine apparatus size and shape on the spatio-temporal dynamics of second messengers using mathematical modeling using reaction-diffusion equations in idealized geometries (ellipsoids, spheres, and mushroom-shaped). Our analyses and simulations showed that in the short timescale, spine size and shape coupled with the spine apparatus geometries govern the spatiotemporal dynamics of second messengers. We show that the curvature of the geometries gives rise to pseudo-harmonic functions, which predict the locations of maximum and minimum concentrations along the spine head. Furthermore, we showed that the lifetime of the concentration gradient can be fine-tuned by localization of fluxes on the spine head and varying the relative curvatures and distances between the spine apparatus and the spine head. Thus, we have identified several key geometric determinants of how the spine head and spine apparatus may regulate the short timescale chemical dynamics of small molecules that control synaptic plasticity." @default.
- W2896075424 created "2018-10-26" @default.
- W2896075424 creator A5009748898 @default.
- W2896075424 creator A5027860030 @default.
- W2896075424 creator A5030570389 @default.
- W2896075424 creator A5044141636 @default.
- W2896075424 creator A5065778793 @default.
- W2896075424 date "2018-10-16" @default.
- W2896075424 modified "2023-10-02" @default.
- W2896075424 title "Geometric principles of second messenger dynamics in dendritic spines" @default.
- W2896075424 cites W150897306 @default.
- W2896075424 cites W1597375909 @default.
- W2896075424 cites W1902144670 @default.
- W2896075424 cites W1966999034 @default.
- W2896075424 cites W1968877074 @default.
- W2896075424 cites W1968912342 @default.
- W2896075424 cites W1983350404 @default.
- W2896075424 cites W1984575885 @default.
- W2896075424 cites W1984924474 @default.
- W2896075424 cites W1988511295 @default.
- W2896075424 cites W1995816184 @default.
- W2896075424 cites W1997105777 @default.
- W2896075424 cites W1998597603 @default.
- W2896075424 cites W2004409231 @default.
- W2896075424 cites W2005641938 @default.
- W2896075424 cites W2007263885 @default.
- W2896075424 cites W2008390024 @default.
- W2896075424 cites W2015557754 @default.
- W2896075424 cites W2017012715 @default.
- W2896075424 cites W2017613746 @default.
- W2896075424 cites W2032123789 @default.
- W2896075424 cites W2034758332 @default.
- W2896075424 cites W2041032780 @default.
- W2896075424 cites W2050282067 @default.
- W2896075424 cites W2054930376 @default.
- W2896075424 cites W2061111257 @default.
- W2896075424 cites W2063731290 @default.
- W2896075424 cites W2065475665 @default.
- W2896075424 cites W2073511180 @default.
- W2896075424 cites W2082246938 @default.
- W2896075424 cites W2083414286 @default.
- W2896075424 cites W2090043895 @default.
- W2896075424 cites W2090178344 @default.
- W2896075424 cites W2093013362 @default.
- W2896075424 cites W2095249350 @default.
- W2896075424 cites W2097979607 @default.
- W2896075424 cites W2101234232 @default.
- W2896075424 cites W2109950649 @default.
- W2896075424 cites W2111155182 @default.
- W2896075424 cites W2122253235 @default.
- W2896075424 cites W2131039108 @default.
- W2896075424 cites W2133667940 @default.
- W2896075424 cites W2137096994 @default.
- W2896075424 cites W2139828787 @default.
- W2896075424 cites W2140030356 @default.
- W2896075424 cites W2143477348 @default.
- W2896075424 cites W2148714108 @default.
- W2896075424 cites W2154045630 @default.
- W2896075424 cites W2154356903 @default.
- W2896075424 cites W2155773585 @default.
- W2896075424 cites W2159374919 @default.
- W2896075424 cites W2163895781 @default.
- W2896075424 cites W2169381819 @default.
- W2896075424 cites W2170247733 @default.
- W2896075424 cites W2221233020 @default.
- W2896075424 cites W2228631656 @default.
- W2896075424 cites W2305464094 @default.
- W2896075424 cites W2331092202 @default.
- W2896075424 cites W2490540212 @default.
- W2896075424 cites W2495137125 @default.
- W2896075424 cites W2508450936 @default.
- W2896075424 cites W2518276547 @default.
- W2896075424 cites W2527653013 @default.
- W2896075424 cites W2549976854 @default.
- W2896075424 cites W2586467030 @default.
- W2896075424 cites W2618988158 @default.
- W2896075424 cites W2751889032 @default.
- W2896075424 cites W2775116549 @default.
- W2896075424 cites W2795091386 @default.
- W2896075424 cites W2886536865 @default.
- W2896075424 cites W2908553168 @default.
- W2896075424 cites W2908824743 @default.
- W2896075424 cites W3012019330 @default.
- W2896075424 cites W3084409310 @default.
- W2896075424 cites W4239375937 @default.
- W2896075424 doi "https://doi.org/10.1101/444489" @default.
- W2896075424 hasPublicationYear "2018" @default.
- W2896075424 type Work @default.
- W2896075424 sameAs 2896075424 @default.
- W2896075424 citedByCount "5" @default.
- W2896075424 countsByYear W28960754242018 @default.
- W2896075424 countsByYear W28960754242019 @default.
- W2896075424 countsByYear W28960754242020 @default.
- W2896075424 countsByYear W28960754242023 @default.
- W2896075424 crossrefType "posted-content" @default.
- W2896075424 hasAuthorship W2896075424A5009748898 @default.
- W2896075424 hasAuthorship W2896075424A5027860030 @default.
- W2896075424 hasAuthorship W2896075424A5030570389 @default.
- W2896075424 hasAuthorship W2896075424A5044141636 @default.
- W2896075424 hasAuthorship W2896075424A5065778793 @default.