FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896077102> ?p ?o ?g. }

• W2896077102 endingPage "472" @default.
• W2896077102 startingPage "463" @default.
• W2896077102 abstract "A bulk of cholesteryl esters accumulation in macrophage foam cells drives the occurrence and development of atherosclerosis. Evidence now shows that autophagy plays key roles in the degradation of intracellular lipid droplets via autolysosome, and also in the release of intracellular lipids via cholesterol efflux. In this study, we identified that a mitochondria-targeted antioxidant, Mito-Tempol, has protective effects against cholesteryl esters accumulation by activating autophagy. Mito-Tempol was shown to ameliorate the lipid burden for atherosclerosis, both in vitro and in vivo. In the established in vitro foam cell formation system using oxidized low-density lipoprotein (ox-LDL)-loaded THP-1 macrophages, Mito-Tempol prevented intracellular oxidative stress and attenuated lipid accumulation. Mito-Tempol rescued ox-LDL-impaired autophagic flux, thereby facilitating autophagy-mediated lipid degradation in THP-1 macrophages. Meanwhile, Mito-Tempol also increased the efflux of cholesterol via autophagy-dependent ABCA1 and ABCG1 up-regulation. The classical autophagy pathway of mTOR may be one of the effector for the autophagy restoration of Mito-Tempol. Our findings give the first insight that cardiovascular system disease may benefits more from the treatment of Mito-Tempol for its impact of reversing atherosclerosis via autophagy." @default.
• W2896077102 created "2018-10-26" @default.
• W2896077102 creator A5012119026 @default.
• W2896077102 creator A5018863416 @default.
• W2896077102 creator A5028926069 @default.
• W2896077102 creator A5029849982 @default.
• W2896077102 creator A5059844880 @default.
• W2896077102 creator A5061972961 @default.
• W2896077102 creator A5066953470 @default.
• W2896077102 creator A5077017777 @default.
• W2896077102 date "2018-12-01" @default.
• W2896077102 modified "2023-10-16" @default.
• W2896077102 title "A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation through restoration of autophagy flux" @default.
• W2896077102 cites W1650965741 @default.
• W2896077102 cites W1968816740 @default.
• W2896077102 cites W1971680920 @default.
• W2896077102 cites W1976621212 @default.
• W2896077102 cites W1983619827 @default.
• W2896077102 cites W1984495784 @default.
• W2896077102 cites W1984931573 @default.
• W2896077102 cites W1987777400 @default.
• W2896077102 cites W1988747541 @default.
• W2896077102 cites W1989605865 @default.
• W2896077102 cites W1996983679 @default.
• W2896077102 cites W1997684038 @default.
• W2896077102 cites W2007505836 @default.
• W2896077102 cites W2017965220 @default.
• W2896077102 cites W2027393658 @default.
• W2896077102 cites W2033354566 @default.
• W2896077102 cites W2039791966 @default.
• W2896077102 cites W2058659027 @default.
• W2896077102 cites W2063337868 @default.
• W2896077102 cites W2067138633 @default.
• W2896077102 cites W2080944896 @default.
• W2896077102 cites W2087647782 @default.
• W2896077102 cites W2092628520 @default.
• W2896077102 cites W2094629035 @default.
• W2896077102 cites W2098361365 @default.
• W2896077102 cites W2144401190 @default.
• W2896077102 cites W2162967025 @default.
• W2896077102 cites W2163788889 @default.
• W2896077102 cites W2164778558 @default.
• W2896077102 cites W2219331970 @default.
• W2896077102 cites W2344690730 @default.
• W2896077102 cites W2547535704 @default.
• W2896077102 cites W2622831252 @default.
• W2896077102 cites W2756275131 @default.
• W2896077102 doi "https://doi.org/10.1016/j.freeradbiomed.2018.10.412" @default.
• W2896077102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30321700" @default.
• W2896077102 hasPublicationYear "2018" @default.
• W2896077102 type Work @default.
• W2896077102 sameAs 2896077102 @default.
• W2896077102 citedByCount "28" @default.
• W2896077102 countsByYear W28960771022019 @default.
• W2896077102 countsByYear W28960771022020 @default.
• W2896077102 countsByYear W28960771022021 @default.
• W2896077102 countsByYear W28960771022022 @default.
• W2896077102 countsByYear W28960771022023 @default.
• W2896077102 crossrefType "journal-article" @default.
• W2896077102 hasAuthorship W2896077102A5012119026 @default.
• W2896077102 hasAuthorship W2896077102A5018863416 @default.
• W2896077102 hasAuthorship W2896077102A5028926069 @default.
• W2896077102 hasAuthorship W2896077102A5029849982 @default.
• W2896077102 hasAuthorship W2896077102A5059844880 @default.
• W2896077102 hasAuthorship W2896077102A5061972961 @default.
• W2896077102 hasAuthorship W2896077102A5066953470 @default.
• W2896077102 hasAuthorship W2896077102A5077017777 @default.
• W2896077102 hasConcept C104317684 @default.
• W2896077102 hasConcept C149011108 @default.
• W2896077102 hasConcept C178790620 @default.
• W2896077102 hasConcept C185592680 @default.
• W2896077102 hasConcept C190283241 @default.
• W2896077102 hasConcept C203522944 @default.
• W2896077102 hasConcept C25095133 @default.
• W2896077102 hasConcept C2776151105 @default.
• W2896077102 hasConcept C2776330080 @default.
• W2896077102 hasConcept C2777704780 @default.
• W2896077102 hasConcept C2777895019 @default.
• W2896077102 hasConcept C2778004101 @default.
• W2896077102 hasConcept C2778163477 @default.
• W2896077102 hasConcept C2780072125 @default.
• W2896077102 hasConcept C55493867 @default.
• W2896077102 hasConcept C68709404 @default.
• W2896077102 hasConcept C79879829 @default.
• W2896077102 hasConcept C86803240 @default.
• W2896077102 hasConcept C95444343 @default.
• W2896077102 hasConceptScore W2896077102C104317684 @default.
• W2896077102 hasConceptScore W2896077102C149011108 @default.
• W2896077102 hasConceptScore W2896077102C178790620 @default.
• W2896077102 hasConceptScore W2896077102C185592680 @default.
• W2896077102 hasConceptScore W2896077102C190283241 @default.
• W2896077102 hasConceptScore W2896077102C203522944 @default.
• W2896077102 hasConceptScore W2896077102C25095133 @default.
• W2896077102 hasConceptScore W2896077102C2776151105 @default.
• W2896077102 hasConceptScore W2896077102C2776330080 @default.
• W2896077102 hasConceptScore W2896077102C2777704780 @default.
• W2896077102 hasConceptScore W2896077102C2777895019 @default.
• W2896077102 hasConceptScore W2896077102C2778004101 @default.

• next