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• W2896077670 endingPage "e0205697" @default.
• W2896077670 startingPage "e0205697" @default.
• W2896077670 abstract "Telomere length has been associated with risk of several cancers. However, studies of the relationship between telomere length and colorectal cancer risk have been inconsistent. This study examined the relationship between telomere length in normal colon tissue and the prevalence of colorectal adenoma, a precursor to colorectal cancer. This nested case-control study consisted of 85 patients aged 40 to 65 undergoing a screening colonoscopy: 40 cases with adenoma(s) detected at colonoscopy and 45 controls with normal colonoscopy. During the colonoscopy, two pinch biopsies of healthy, normal appearing mucosa were obtained from the descending colon. Relative telomere length (rTL) was quantified in DNA extracted from colon mucosa using quantitative real-time PCR. Logistic regression was used to assess the relationship between telomere length and adenoma prevalence and estimate odds ratios and 95% confidence intervals. rTL was significantly longer in colon tissue of individuals with adenomas compared to healthy individuals (p = 0.008). When rTL was categorized into quartiles according to the distribution of rTL among controls, individuals with the longest telomeres had increased odds of adenoma when compared to individuals with shortest telomeres (OR = 4.58, 95% CI: 1.19, 17.7). This study suggests that long telomeres in normal colon tissue are associated with increased colorectal cancer risk." @default.
• W2896077670 created "2018-10-26" @default.
• W2896077670 creator A5012521553 @default.
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• W2896077670 creator A5089411633 @default.
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• W2896077670 date "2018-10-17" @default.
• W2896077670 modified "2023-09-27" @default.
• W2896077670 title "Telomere length in the colon is related to colorectal adenoma prevalence" @default.
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• W2896077670 doi "https://doi.org/10.1371/journal.pone.0205697" @default.
• W2896077670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192597" @default.
• W2896077670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30332457" @default.
• W2896077670 hasPublicationYear "2018" @default.
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