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- W2896078611 abstract "Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures. Recent findings have linked the microbiota to gastrointestinal disorders characterized by abdominal pain suggesting the ability of microbes to modulate visceral hypersensitivity and nociception to pain.In this review we describe the neuroanatomical basis of visceral pain signaling and the existing evidence of its manipulation exerted by the gut microbiota. We included an updated overview of the potential therapeutic effects of dietary intervention, specifically probiotics and prebiotics, in alleviating hypersensitivity to visceral pain stimuli.The gut microbiota dramatically impacts normal visceral pain sensation and affects the mechanisms mediating visceral nociception. Furthermore, manipulation of the gut microbiota using prebiotics and probiotics plays a potential role in the regulation of visceral pain disorders." @default.
- W2896078611 created "2018-10-26" @default.
- W2896078611 creator A5004750707 @default.
- W2896078611 creator A5071979996 @default.
- W2896078611 date "2018-10-11" @default.
- W2896078611 modified "2023-10-14" @default.
- W2896078611 title "Visceral pain: gut microbiota, a new hope?" @default.
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- W2896078611 doi "https://doi.org/10.1186/s12929-018-0476-7" @default.
- W2896078611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6182804" @default.
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- W2896078611 hasPublicationYear "2018" @default.
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