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• W2896079738 endingPage "2596" @default.
• W2896079738 startingPage "2586" @default.
• W2896079738 abstract "Acute pancreatitis is an inflammatory disorder of the pancreas that may precipitate due to various reasons such as chronic alcoholism, gall stone obstruction, and life style. Current treatment options offer limited efficacy, as they provide only symptomatic relief. This study is an attempt to study the effects of Withaferin A (WFA) against Cerulein‐induced acute pancreatitis in mice. Animals were pretreated with WFA via intraperitoneal route, for 7 days. Plasma amylase and lipase, tissue malondialdehyde (MDA), and glutathione were evaluated for all groups. Western blot analysis; haematoxylin and eosin staining of the liver, lung, and pancreas; immunohistochemistry for nitrotyrosine; and myeloperoxidase activity were performed. Haematoxylin and eosin stained sections significantly revealed the altered architecture and thereby damage in the pancreas, lungs, and liver that has been low in treatment groups. Increased myeloperoxidase and nitrotyrosine have also been reduced upon treatment with WFA. Increased levels of MDA, NO, and expression of myeloperoxidase and nitrotyrosine in the parameters estimated add evidence to the role of oxidative stress and inflammation in acute pancreatitis. WFA evidently altered these conditions upon pretreatment. Our study shows that this novel steroidal compound has potent anti‐inflammatory property. Natural compounds can therefore be good remedies against many diseases if incorporated in routine diet as dietary supplement." @default.
• W2896079738 created "2018-10-26" @default.
• W2896079738 creator A5016946544 @default.
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• W2896079738 date "2018-10-11" @default.
• W2896079738 modified "2023-10-18" @default.
• W2896079738 title "Withaferin <scp>A</scp>, a novel compound of <scp>I</scp>ndian ginseng (<scp><i>Withania somnifera</i></scp>), ameliorates <scp>C</scp>erulein‐induced acute pancreatitis: Possible role of oxidative stress and inflammation" @default.
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• W2896079738 doi "https://doi.org/10.1002/ptr.6200" @default.
• W2896079738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307087" @default.
• W2896079738 hasPublicationYear "2018" @default.
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