Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896080170> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2896080170 endingPage "213" @default.
- W2896080170 startingPage "206" @default.
- W2896080170 abstract "Candida albicans is frequently associated with mixed infections of Streptococcus mutans in plaque biofilms. These pathogens under chemical interactions resulting in mixed biofilm development have turned it into a prevalent and costly oral disease, which is not successfully being treated by existing chemotherapeutics. Considering the need for newer drugs to overcome this challenge, the present study was aimed to investigate the efficacy of eugenol in inhibiting single and mixed biofilms of C. albicans and S. mutans. The broth dilution assay was used to determine drug resistance in the test strains. Biofilm formation on polystyrene microtiter plate was studied by XTT reduction assay whereas biofilm development on glass coverslips was assessed using 0.1% crystal violet and visualised under light microscope. Single and mixed biofilms formed on glass coverslips in the presence and absence of eugenol was analysed by scanning electron microscopy. In our study, all the thirteen strains of C. albicans were resistant to fluconazole, itraconazole, ketoconazole, amphotericin B except C. albicans (CAJ-01) and C. albicans MTCC3017 which were sensitive to fluconazole. S. mutans MTCC497 was resistant to ampicillin, azithromycin, ceftriaxone and vancomycin. Among all the strains of C. albicans, CAJ-01, C. albicans ATCC90028 and C. albicans MTCC3017 formed strong biofilms and rest of the strains considered as moderate to weak biofilm formers. S. mutans MTCC497 was also formed strong biofilms. Eugenol showed concentration dependent anti-biofilm activity against single and mixed biofilms of C. albicans (CAJ-01) and S. mutans MTCC497. At sub-MIC of eugenol (100 μg/ml), the biofilm formation was 36.37% and 29.72% in CAJ-01 and S. mutans MTCC497, respectively, whereas 52.65% in mixed biofilms. The cell viability assay showed significant reduction (p < 0.05) in the log10 CFU/ml from 6.3 to 4.8 at 200 μg/ml of eugenol for CAJ-01, whereas, from 6.4 to 3.8 and 5.3 for S. mutans MTCC497 strains in single and mixed biofilms, respectively. Scanning electron microscopy showed the disruption of cell membrane and matrix structure in both single and mixed biofilms. Eugenol at sub-MICs effectively inhibited single and mixed biofilms formed by the drug resistant strains of two oral pathogens, C. albicans and S. mutans through multiple mode of action." @default.
- W2896080170 created "2018-10-26" @default.
- W2896080170 creator A5016858713 @default.
- W2896080170 creator A5026426721 @default.
- W2896080170 creator A5082119419 @default.
- W2896080170 date "2019-02-01" @default.
- W2896080170 modified "2023-10-13" @default.
- W2896080170 title "In vitro efficacy of eugenol in inhibiting single and mixed-biofilms of drug-resistant strains of Candida albicans and Streptococcus mutans" @default.
- W2896080170 cites W1968846907 @default.
- W2896080170 cites W1995149284 @default.
- W2896080170 cites W1997897577 @default.
- W2896080170 cites W2001470688 @default.
- W2896080170 cites W2007448189 @default.
- W2896080170 cites W2050745388 @default.
- W2896080170 cites W2057583358 @default.
- W2896080170 cites W2070090700 @default.
- W2896080170 cites W2070458089 @default.
- W2896080170 cites W2088268075 @default.
- W2896080170 cites W2103333884 @default.
- W2896080170 cites W2108386026 @default.
- W2896080170 cites W2110892287 @default.
- W2896080170 cites W2137701517 @default.
- W2896080170 cites W2140173686 @default.
- W2896080170 cites W2154818633 @default.
- W2896080170 cites W2162028376 @default.
- W2896080170 cites W2173365940 @default.
- W2896080170 cites W2189428702 @default.
- W2896080170 cites W2289444717 @default.
- W2896080170 cites W2300859708 @default.
- W2896080170 cites W2343689319 @default.
- W2896080170 cites W2626920017 @default.
- W2896080170 cites W2730753403 @default.
- W2896080170 cites W2738323036 @default.
- W2896080170 cites W2745077547 @default.
- W2896080170 cites W2748680352 @default.
- W2896080170 cites W2760799263 @default.
- W2896080170 cites W4211031197 @default.
- W2896080170 cites W756049019 @default.
- W2896080170 doi "https://doi.org/10.1016/j.phymed.2018.10.005" @default.
- W2896080170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30668370" @default.
- W2896080170 hasPublicationYear "2019" @default.
- W2896080170 type Work @default.
- W2896080170 sameAs 2896080170 @default.
- W2896080170 citedByCount "43" @default.
- W2896080170 countsByYear W28960801702019 @default.
- W2896080170 countsByYear W28960801702020 @default.
- W2896080170 countsByYear W28960801702021 @default.
- W2896080170 countsByYear W28960801702022 @default.
- W2896080170 countsByYear W28960801702023 @default.
- W2896080170 crossrefType "journal-article" @default.
- W2896080170 hasAuthorship W2896080170A5016858713 @default.
- W2896080170 hasAuthorship W2896080170A5026426721 @default.
- W2896080170 hasAuthorship W2896080170A5082119419 @default.
- W2896080170 hasConcept C145081991 @default.
- W2896080170 hasConcept C178790620 @default.
- W2896080170 hasConcept C185592680 @default.
- W2896080170 hasConcept C2778430296 @default.
- W2896080170 hasConcept C2779548794 @default.
- W2896080170 hasConcept C2780470866 @default.
- W2896080170 hasConcept C2780651595 @default.
- W2896080170 hasConcept C2780917455 @default.
- W2896080170 hasConcept C523546767 @default.
- W2896080170 hasConcept C54355233 @default.
- W2896080170 hasConcept C58123911 @default.
- W2896080170 hasConcept C86803240 @default.
- W2896080170 hasConcept C89423630 @default.
- W2896080170 hasConceptScore W2896080170C145081991 @default.
- W2896080170 hasConceptScore W2896080170C178790620 @default.
- W2896080170 hasConceptScore W2896080170C185592680 @default.
- W2896080170 hasConceptScore W2896080170C2778430296 @default.
- W2896080170 hasConceptScore W2896080170C2779548794 @default.
- W2896080170 hasConceptScore W2896080170C2780470866 @default.
- W2896080170 hasConceptScore W2896080170C2780651595 @default.
- W2896080170 hasConceptScore W2896080170C2780917455 @default.
- W2896080170 hasConceptScore W2896080170C523546767 @default.
- W2896080170 hasConceptScore W2896080170C54355233 @default.
- W2896080170 hasConceptScore W2896080170C58123911 @default.
- W2896080170 hasConceptScore W2896080170C86803240 @default.
- W2896080170 hasConceptScore W2896080170C89423630 @default.
- W2896080170 hasLocation W28960801701 @default.
- W2896080170 hasLocation W28960801702 @default.
- W2896080170 hasOpenAccess W2896080170 @default.
- W2896080170 hasPrimaryLocation W28960801701 @default.
- W2896080170 hasRelatedWork W1951367654 @default.
- W2896080170 hasRelatedWork W2028319462 @default.
- W2896080170 hasRelatedWork W2102861863 @default.
- W2896080170 hasRelatedWork W2247003880 @default.
- W2896080170 hasRelatedWork W2356995717 @default.
- W2896080170 hasRelatedWork W2367173716 @default.
- W2896080170 hasRelatedWork W2742010288 @default.
- W2896080170 hasRelatedWork W2778267304 @default.
- W2896080170 hasRelatedWork W3029732278 @default.
- W2896080170 hasRelatedWork W4362508968 @default.
- W2896080170 hasVolume "54" @default.
- W2896080170 isParatext "false" @default.
- W2896080170 isRetracted "false" @default.
- W2896080170 magId "2896080170" @default.
- W2896080170 workType "article" @default.