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• W2896083380 abstract "Significance There is a strong need for new analgesic and antiinflammatory medicines that are both effective and safe. Animal studies have shown that inhibition of N -acylethanolamine acid amidase (NAAA)—an intracellular enzyme that degrades the lipid mediator palmitoylethanolamide—causes profound analgesic and antiinflammatory effects. To facilitate the discovery of drugs targeting this protein and to better understand its mechanism of action, we determined its 3D structure. Our results illustrate the sequential steps leading to the activation of NAAA at lipid membranes, and reveal how current inhibitors block this enzyme." @default.
• W2896083380 created "2018-10-26" @default.
• W2896083380 creator A5031213755 @default.
• W2896083380 creator A5042516545 @default.
• W2896083380 creator A5080469642 @default.
• W2896083380 creator A5087000930 @default.
• W2896083380 creator A5087373098 @default.
• W2896083380 date "2018-10-09" @default.
• W2896083380 modified "2023-10-16" @default.
• W2896083380 title "Molecular mechanism of activation of the immunoregulatory amidase NAAA" @default.
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• W2896083380 doi "https://doi.org/10.1073/pnas.1811759115" @default.
• W2896083380 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6205464" @default.

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