FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896085429> ?p ?o ?g. }

• W2896085429 abstract "Abstract We observed that heat shock of Caenorhabditis elegans leads to the formation of nuclear double-stranded RNA (dsRNA) foci, detectable with a dsRNA-specific monoclonal antibody. These foci significantly overlap with nuclear HSF-1 granules. To investigate the molecular mechanism(s) underlying dsRNA foci formation, we used RNA-seq to globally characterize total RNA and immunoprecipitated dsRNA from control and heat shocked worms. We find antisense transcripts are generally increased after heat shock, and a subset of both sense and antisense transcripts enriched in the dsRNA pool by heat shock overlap with dsRNA transcripts enriched by deletion of tdp-1, which encodes the C. elegans ortholog of TDP-43. Interestingly, transcripts involved in translation are over-represented in the dsRNAs induced by either heat shock or deletion of tdp-1. Also enriched in the dsRNA transcripts are sequences downstream of annotated genes (DoGs), which we globally quantified with a new algorithm. To validate these observations, we used fluorescence in situ hybridization (FISH) to confirm both antisense and downstream of gene transcription for eif-3.B, one of the affected loci we identified." @default.
• W2896085429 created "2018-10-26" @default.
• W2896085429 creator A5016071390 @default.
• W2896085429 creator A5047723041 @default.
• W2896085429 creator A5050614625 @default.
• W2896085429 creator A5071757596 @default.
• W2896085429 creator A5083753737 @default.
• W2896085429 creator A5088162537 @default.
• W2896085429 date "2018-10-19" @default.
• W2896085429 modified "2023-09-27" @default.
• W2896085429 title "Heat Shock in C. elegans Induces Downstream of Gene Transcription andAccumulation of Double-Stranded RNA" @default.
• W2896085429 cites W1519422934 @default.
• W2896085429 cites W1560069809 @default.
• W2896085429 cites W1882171616 @default.
• W2896085429 cites W1970707135 @default.
• W2896085429 cites W2008334829 @default.
• W2896085429 cites W2024858047 @default.
• W2896085429 cites W2032747284 @default.
• W2896085429 cites W2037313242 @default.
• W2896085429 cites W2040359453 @default.
• W2896085429 cites W2048438868 @default.
• W2896085429 cites W2065785051 @default.
• W2896085429 cites W2069030183 @default.
• W2896085429 cites W2069888159 @default.
• W2896085429 cites W2078779750 @default.
• W2896085429 cites W2085350682 @default.
• W2896085429 cites W2104431515 @default.
• W2896085429 cites W2117131162 @default.
• W2896085429 cites W2124565600 @default.
• W2896085429 cites W2131271579 @default.
• W2896085429 cites W2136170412 @default.
• W2896085429 cites W2138207763 @default.
• W2896085429 cites W2140750082 @default.
• W2896085429 cites W2159565935 @default.
• W2896085429 cites W2165113979 @default.
• W2896085429 cites W2170634816 @default.
• W2896085429 cites W2173001211 @default.
• W2896085429 cites W2175647688 @default.
• W2896085429 cites W2416819443 @default.
• W2896085429 cites W2750745925 @default.
• W2896085429 cites W2755390119 @default.
• W2896085429 cites W2768145059 @default.
• W2896085429 cites W2845591014 @default.
• W2896085429 doi "https://doi.org/10.1101/448233" @default.
• W2896085429 hasPublicationYear "2018" @default.
• W2896085429 type Work @default.
• W2896085429 sameAs 2896085429 @default.
• W2896085429 citedByCount "0" @default.
• W2896085429 crossrefType "posted-content" @default.
• W2896085429 hasAuthorship W2896085429A5016071390 @default.
• W2896085429 hasAuthorship W2896085429A5047723041 @default.
• W2896085429 hasAuthorship W2896085429A5050614625 @default.
• W2896085429 hasAuthorship W2896085429A5071757596 @default.
• W2896085429 hasAuthorship W2896085429A5083753737 @default.
• W2896085429 hasAuthorship W2896085429A5088162537 @default.
• W2896085429 hasBestOaLocation W28960854291 @default.
• W2896085429 hasConcept C104317684 @default.
• W2896085429 hasConcept C105580179 @default.
• W2896085429 hasConcept C138885662 @default.
• W2896085429 hasConcept C153911025 @default.
• W2896085429 hasConcept C166703698 @default.
• W2896085429 hasConcept C179926584 @default.
• W2896085429 hasConcept C205260736 @default.
• W2896085429 hasConcept C2191507 @default.
• W2896085429 hasConcept C2778944004 @default.
• W2896085429 hasConcept C41895202 @default.
• W2896085429 hasConcept C54355233 @default.
• W2896085429 hasConcept C67705224 @default.
• W2896085429 hasConcept C86803240 @default.
• W2896085429 hasConcept C95444343 @default.
• W2896085429 hasConceptScore W2896085429C104317684 @default.
• W2896085429 hasConceptScore W2896085429C105580179 @default.
• W2896085429 hasConceptScore W2896085429C138885662 @default.
• W2896085429 hasConceptScore W2896085429C153911025 @default.
• W2896085429 hasConceptScore W2896085429C166703698 @default.
• W2896085429 hasConceptScore W2896085429C179926584 @default.
• W2896085429 hasConceptScore W2896085429C205260736 @default.
• W2896085429 hasConceptScore W2896085429C2191507 @default.
• W2896085429 hasConceptScore W2896085429C2778944004 @default.
• W2896085429 hasConceptScore W2896085429C41895202 @default.
• W2896085429 hasConceptScore W2896085429C54355233 @default.
• W2896085429 hasConceptScore W2896085429C67705224 @default.
• W2896085429 hasConceptScore W2896085429C86803240 @default.
• W2896085429 hasConceptScore W2896085429C95444343 @default.
• W2896085429 hasLocation W28960854291 @default.
• W2896085429 hasLocation W28960854292 @default.
• W2896085429 hasLocation W28960854293 @default.
• W2896085429 hasLocation W28960854294 @default.
• W2896085429 hasOpenAccess W2896085429 @default.
• W2896085429 hasPrimaryLocation W28960854291 @default.
• W2896085429 hasRelatedWork W1979220165 @default.
• W2896085429 hasRelatedWork W2062947011 @default.
• W2896085429 hasRelatedWork W2156806727 @default.
• W2896085429 hasRelatedWork W2183051557 @default.
• W2896085429 hasRelatedWork W2206816865 @default.
• W2896085429 hasRelatedWork W2399809831 @default.
• W2896085429 hasRelatedWork W2465106488 @default.
• W2896085429 hasRelatedWork W2896085429 @default.
• W2896085429 hasRelatedWork W2950795148 @default.
• W2896085429 hasRelatedWork W4249220449 @default.

• next