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• W2896085576 abstract "Long non-coding RNA (LncRNA) brain-derived neurotrophic factor antisense (BDNF-AS) has been found to be down-regulated and function in a tumor suppressive role in human cancers. However, the expression status and function of BDNF-AS is still unknown in osteosarcoma (OS). In our study, BDNF-AS expression was found to be decreased in OS tissues and cells. Moreover, BDNF-AS low expression was correlated with advanced Enneking stage, large tumor size and poor prognosis in OS patients. The multivariate analysis suggested low expression of BDNF-AS was an independent unfavorable prognostic factor for overall survival in OS patients. The in vitro studies indicated that BDNF-AS overexpression inhibits OS cell proliferation and promotes cell apoptosis through regulating cleaved caspase-3. In conclusion, BDNF-AS serves as a tumor suppressive lncRNA in OS." @default.
• W2896085576 created "2018-10-26" @default.
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• W2896085576 date "2018-11-16" @default.
• W2896085576 modified "2023-09-26" @default.
• W2896085576 title "LncRNA BDNF-AS is associated with the malignant status and regulates cell proliferation and apoptosis in osteosarcoma" @default.
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• W2896085576 doi "https://doi.org/10.1042/bsr20181498" @default.
• W2896085576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6240721" @default.
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