FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896087385> ?p ?o ?g. }

• W2896087385 endingPage "205" @default.
• W2896087385 startingPage "195" @default.
• W2896087385 abstract "Background Atypical small acinar proliferation (ASAP) is a precursor lesion of prostate cancer (PC), and PC develops from this suspicious focus or an unsampled malignant gland nearby. However, PC‐related molecular alterations that could guide the timing of repeat biopsies and help monitor PC risk in ASAP‐diagnosed patients have not been investigated. The purpose of this study was to first investigate the expression of seven different PC‐related RNAs that included serine 2 ( TMPRSS2 ): erythroblastosis virus E26 oncogene homolog ( ERG ) gene ( TMPRSS2‐ERG , T2E ) fusion, alpha‐methylacyl‐CoA racemase ( AMACR ), kallikrein related peptidase 3 ( KLK3 ), androgen receptor ( AR ), prostate cancer specific antigen 3 ( PCA3 ), and matrix metalloproteinases ( MMP )‐2 and 9. Methods PC‐related RNAs were evaluated using a real‐time quantitative reverse transcription polymerase chain reaction (RT‐qPCR) system in pathologically ASAP‐diagnosed prostate biopsy cores from 55 patients presenting with a normal digital rectal examination and a PSA level of 4‐10 ng/mL. Results We detected that positive T2E fusion status ( P = 0.013) and the expression of AMACR ( P = 0.016 ) , AR ( P = 0.016 ) and MMP ‐2 ( P = 0.013) were independently and significantly associated with PC risk in ASAP patients. There were also several statistically significant correlations between expression levels. Additionally, we demonstrated that T2E fusion positive ASAP patients with higher MMP ‐2 expression were more likely to be diagnosed with PC at a subsequent biopsy during the follow‐up period ( P = 0.003). Conclusions Although, more clinical validations are needed for the stratification of PC risk in ASAP‐diagnosed biopsy cores, our current results indicate that the coexistence of T 2 E fusion positivity with MMP ‐2 upregulation may help clinicians adjust their biopsy timetable and/or assessment of PC risk in ASAP‐diagnosed patients with a PSA level of 4‐10 ng/mL." @default.
• W2896087385 created "2018-10-26" @default.
• W2896087385 creator A5007333593 @default.
• W2896087385 creator A5008243420 @default.
• W2896087385 creator A5019983388 @default.
• W2896087385 creator A5020975641 @default.
• W2896087385 creator A5045427429 @default.
• W2896087385 creator A5048329903 @default.
• W2896087385 creator A5075288283 @default.
• W2896087385 date "2018-10-07" @default.
• W2896087385 modified "2023-10-01" @default.
• W2896087385 title "RNA‐based markers in biopsy cores with atypical small acinar proliferation: Predictive effect of<i>T2E</i>fusion positivity and<i>MMP‐2</i>upregulation for a subsequent prostate cancer diagnosis" @default.
• W2896087385 cites W108996958 @default.
• W2896087385 cites W1430602261 @default.
• W2896087385 cites W1598670606 @default.
• W2896087385 cites W16600773 @default.
• W2896087385 cites W1803194864 @default.
• W2896087385 cites W1904209801 @default.
• W2896087385 cites W1966056172 @default.
• W2896087385 cites W1972309806 @default.
• W2896087385 cites W1981869338 @default.
• W2896087385 cites W1982014262 @default.
• W2896087385 cites W1982956208 @default.
• W2896087385 cites W1985550922 @default.
• W2896087385 cites W1989764260 @default.
• W2896087385 cites W1990418085 @default.
• W2896087385 cites W2003594114 @default.
• W2896087385 cites W2005658600 @default.
• W2896087385 cites W2006190057 @default.
• W2896087385 cites W2006280280 @default.
• W2896087385 cites W2013278694 @default.
• W2896087385 cites W2018795692 @default.
• W2896087385 cites W2024432096 @default.
• W2896087385 cites W2025855191 @default.
• W2896087385 cites W2028992206 @default.
• W2896087385 cites W2035936829 @default.
• W2896087385 cites W2038780502 @default.
• W2896087385 cites W2050973520 @default.
• W2896087385 cites W2054988536 @default.
• W2896087385 cites W2058532211 @default.
• W2896087385 cites W2061891797 @default.
• W2896087385 cites W2072997351 @default.
• W2896087385 cites W2077438659 @default.
• W2896087385 cites W2079298594 @default.
• W2896087385 cites W2082887107 @default.
• W2896087385 cites W2082970232 @default.
• W2896087385 cites W2092080113 @default.
• W2896087385 cites W2093030736 @default.
• W2896087385 cites W2109954086 @default.
• W2896087385 cites W2113670094 @default.
• W2896087385 cites W2121158863 @default.
• W2896087385 cites W2123108263 @default.
• W2896087385 cites W2127625592 @default.
• W2896087385 cites W2128536507 @default.
• W2896087385 cites W2129706773 @default.
• W2896087385 cites W2133328863 @default.
• W2896087385 cites W2137934906 @default.
• W2896087385 cites W2153162303 @default.
• W2896087385 cites W2157784108 @default.
• W2896087385 cites W2160947271 @default.
• W2896087385 cites W2161315124 @default.
• W2896087385 cites W2163662536 @default.
• W2896087385 cites W2165834169 @default.
• W2896087385 cites W2198027699 @default.
• W2896087385 cites W2254244760 @default.
• W2896087385 cites W2287071251 @default.
• W2896087385 cites W2291006448 @default.
• W2896087385 cites W2296343843 @default.
• W2896087385 cites W2333003097 @default.
• W2896087385 cites W2410090437 @default.
• W2896087385 cites W2424766243 @default.
• W2896087385 cites W2606219947 @default.
• W2896087385 cites W2743559898 @default.
• W2896087385 cites W2745706068 @default.
• W2896087385 cites W2768842469 @default.
• W2896087385 cites W2777340600 @default.
• W2896087385 cites W2792579669 @default.
• W2896087385 cites W2803246515 @default.
• W2896087385 cites W4237985398 @default.
• W2896087385 cites W4242570784 @default.
• W2896087385 cites W4297682006 @default.
• W2896087385 doi "https://doi.org/10.1002/pros.23724" @default.
• W2896087385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30294801" @default.
• W2896087385 hasPublicationYear "2018" @default.
• W2896087385 type Work @default.
• W2896087385 sameAs 2896087385 @default.
• W2896087385 citedByCount "3" @default.
• W2896087385 countsByYear W28960873852021 @default.
• W2896087385 countsByYear W28960873852023 @default.
• W2896087385 crossrefType "journal-article" @default.
• W2896087385 hasAuthorship W2896087385A5007333593 @default.
• W2896087385 hasAuthorship W2896087385A5008243420 @default.
• W2896087385 hasAuthorship W2896087385A5019983388 @default.
• W2896087385 hasAuthorship W2896087385A5020975641 @default.
• W2896087385 hasAuthorship W2896087385A5045427429 @default.
• W2896087385 hasAuthorship W2896087385A5048329903 @default.
• W2896087385 hasAuthorship W2896087385A5075288283 @default.
• W2896087385 hasConcept C121608353 @default.

• next