Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896087455> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2896087455 endingPage "506" @default.
- W2896087455 startingPage "497" @default.
- W2896087455 abstract "Burosumab (Crysvita®), a fully human IgG1 monoclonal antibody directed at fibroblast growth factor 23 (FGF23), is indicated for the treatment of X-linked hypophosphatemia (XLH), a condition associated with excessive FGF23 production. It directly addresses the excessive FGF23 activity in patients with XLH by binding to FGF23, and inhibiting its signaling. This leads to increased gastrointestinal phosphate absorption and renal phosphate reabsorption, thereby improving serum phosphate levels, and, ultimately, bone mineralization and the risk of bone disease. In clinical trials, subcutaneous burosumab increased serum phosphorus levels in pediatric and adult patients with XLH, as well as significantly improving the severity of rickets in children, and improving pain, stiffness, physical functioning, and fracture/pseudofracture healing in adults. Burosumab is well tolerated by children and adults with XLH, with most treatment-emergent adverse events being of mild to moderate severity." @default.
- W2896087455 created "2018-10-26" @default.
- W2896087455 creator A5037083528 @default.
- W2896087455 date "2018-10-08" @default.
- W2896087455 modified "2023-10-11" @default.
- W2896087455 title "Burosumab in X-linked hypophosphatemia: a profile of its use in the USA" @default.
- W2896087455 cites W1925356513 @default.
- W2896087455 cites W1964204750 @default.
- W2896087455 cites W1985742682 @default.
- W2896087455 cites W2043958868 @default.
- W2896087455 cites W2090490099 @default.
- W2896087455 cites W2153778965 @default.
- W2896087455 cites W2361150752 @default.
- W2896087455 cites W2768285778 @default.
- W2896087455 cites W2790127412 @default.
- W2896087455 cites W2792025859 @default.
- W2896087455 cites W2803769911 @default.
- W2896087455 cites W2810290010 @default.
- W2896087455 cites W3115366140 @default.
- W2896087455 doi "https://doi.org/10.1007/s40267-018-0560-9" @default.
- W2896087455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6223702" @default.
- W2896087455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30459508" @default.
- W2896087455 hasPublicationYear "2018" @default.
- W2896087455 type Work @default.
- W2896087455 sameAs 2896087455 @default.
- W2896087455 citedByCount "13" @default.
- W2896087455 countsByYear W28960874552020 @default.
- W2896087455 countsByYear W28960874552021 @default.
- W2896087455 countsByYear W28960874552022 @default.
- W2896087455 countsByYear W28960874552023 @default.
- W2896087455 crossrefType "journal-article" @default.
- W2896087455 hasAuthorship W2896087455A5037083528 @default.
- W2896087455 hasBestOaLocation W28960874551 @default.
- W2896087455 hasConcept C114276007 @default.
- W2896087455 hasConcept C124490489 @default.
- W2896087455 hasConcept C126322002 @default.
- W2896087455 hasConcept C134018914 @default.
- W2896087455 hasConcept C197934379 @default.
- W2896087455 hasConcept C2776489590 @default.
- W2896087455 hasConcept C2778573388 @default.
- W2896087455 hasConcept C2781208988 @default.
- W2896087455 hasConcept C519063684 @default.
- W2896087455 hasConcept C71924100 @default.
- W2896087455 hasConceptScore W2896087455C114276007 @default.
- W2896087455 hasConceptScore W2896087455C124490489 @default.
- W2896087455 hasConceptScore W2896087455C126322002 @default.
- W2896087455 hasConceptScore W2896087455C134018914 @default.
- W2896087455 hasConceptScore W2896087455C197934379 @default.
- W2896087455 hasConceptScore W2896087455C2776489590 @default.
- W2896087455 hasConceptScore W2896087455C2778573388 @default.
- W2896087455 hasConceptScore W2896087455C2781208988 @default.
- W2896087455 hasConceptScore W2896087455C519063684 @default.
- W2896087455 hasConceptScore W2896087455C71924100 @default.
- W2896087455 hasIssue "11" @default.
- W2896087455 hasLocation W28960874551 @default.
- W2896087455 hasLocation W28960874552 @default.
- W2896087455 hasLocation W28960874553 @default.
- W2896087455 hasLocation W28960874554 @default.
- W2896087455 hasOpenAccess W2896087455 @default.
- W2896087455 hasPrimaryLocation W28960874551 @default.
- W2896087455 hasRelatedWork W1963989624 @default.
- W2896087455 hasRelatedWork W2070972083 @default.
- W2896087455 hasRelatedWork W2100921980 @default.
- W2896087455 hasRelatedWork W2105612511 @default.
- W2896087455 hasRelatedWork W2122235063 @default.
- W2896087455 hasRelatedWork W2129462573 @default.
- W2896087455 hasRelatedWork W2130523537 @default.
- W2896087455 hasRelatedWork W2807650456 @default.
- W2896087455 hasRelatedWork W3199869492 @default.
- W2896087455 hasRelatedWork W4229718260 @default.
- W2896087455 hasVolume "34" @default.
- W2896087455 isParatext "false" @default.
- W2896087455 isRetracted "false" @default.
- W2896087455 magId "2896087455" @default.
- W2896087455 workType "article" @default.