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- W2896089133 abstract "Significance Astrocytes are nonneuronal cells that closely associate with neuronal synapses to regulate synaptic function in brain circuits. A powerful mechanism by which astrocytes can modulate neurotransmission is through their uptake of synaptically released neurotransmitters (NTs). Imbalances in the uptake of the excitatory NT glutamate or inhibitory NT GABBA can change the balance of excitatory and inhibitory signaling in the brain and lead to hyperactivity or seizure. In this study, we explore how astrocytes modulate neuronal hyperactivity and show that focal adhesions, a class of cell-adhesion molecules, are key regulators of astrocyte associations with synapses and astrocyte expression of NT transporters. This work provides potential targets for therapeutic manipulation to suppress seizure activity or excess neuronal excitability." @default.
- W2896089133 created "2018-10-26" @default.
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- W2896089133 date "2018-10-16" @default.
- W2896089133 modified "2023-10-02" @default.
- W2896089133 title "Focal adhesion molecules regulate astrocyte morphology and glutamate transporters to suppress seizure-like behavior" @default.
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- W2896089133 doi "https://doi.org/10.1073/pnas.1800830115" @default.
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