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• W2896090400 abstract "In recent T-cell AIDS vaccine trials, the vaccines did not prevent HIV-1 infection, although HIV-1-specific T cells were induced in the vaccinated individuals, suggesting that the T cells have a weak ability to suppress HIV-1 replication and fail to recognize circulating HIV-1. We previously demonstrated that the T-cell responses to 10 epitopes were significantly associated with good clinical outcome. However, there is no direct evidence that these T cells have strong abilities to suppress HIV-1 replication and recognize circulating HIV-1. Here, we demonstrated that the T cells specific for the 10 epitopes had strong abilities to suppress HIV-1 replication in vitro . Moreover, the T cells cross-recognized most of the circulating HIV-1 in HIV-1-infected individuals. This study suggests the use of T cells specific for these 10 epitopes in clinical trials of T-cell vaccines as a cure treatment." @default.
• W2896090400 created "2018-10-26" @default.
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• W2896090400 date "2019-01-01" @default.
• W2896090400 modified "2023-10-16" @default.
• W2896090400 title "Broad Recognition of Circulating HIV-1 by HIV-1-Specific Cytotoxic T-Lymphocytes with Strong Ability to Suppress HIV-1 Replication" @default.
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• W2896090400 doi "https://doi.org/10.1128/jvi.01480-18" @default.
• W2896090400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6288335" @default.
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