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• W2896091328 abstract "Introduction: Neoadjuvant radiochemotherapy (RT/CTx) regimens were primarily designed for treatment of squamous cell carcinoma (SCC) of the esophagus. Own results demonstrate that also patients with locally advanced adenocarcinoma (AC) of the esophagus may achieve a major response in 30 % with a 3 year survival rate of 80 %. To identify these patients, ERCC1 (rs11615) gene polymorphisms were analyzed. ERCC1 is a key enzyme of the nucleotide excision and repair (NER) complex to prevent DNA inter- and intrastrand crosslinks. Methods: Genomic DNA from 144 patients with adenocarcinoma of the esophagus was extracted from paraffin-embedded tissues. For analysis of ERCC1 single nucleotide polymorphisms (SNPs) allelic discrimination was performed by quantitative realtime PCR. Two allele-specific TaqMan probes in competition were used for amplification of ERCC1 (rs11615). Allelic genotyping was correlated with histomorphologic tumor regression and survival after neoadjuvant RT/CTx. Major response (MaHR) was defined as ≤ 10 % vital residual tumor cells. Results: Analysis of tumor regression revealed a MaHR in 49/144 (34 %) patients with a 5-year survival rate (5-YSR) of 72 % (p = 0.0001). ERCC1 gene polymorphisms for all patients showed the following expression pattern: ERCC1 polymorphism (rs11615) CC: n = 13 (9 %), TT: n = 74 (51 %), CT: n = 57 (40 %). ERCC1 polymorphism CT was identified as a predictor for response to the neoadjuvant RT/CTx (p < 0.001). The 5-YSR for patients with CT genotype was 53 %. Contrary to this, the 5-YSR for the group of patients with a CC/TT-polymorphism decreased to 33 %. Conclusion: Analysis of ERCC1 (rs11615) gene polymorphisms reveals a significant (p < 0.001) correlation with response and survival in patients with adenocarcinoma of the esophagus treated with a neoadjuvant radiochemotherapy (CDDP, 5-FU, 36Gy). Single nucleotide polymorphisms of ERCC1 (rs11615) could therefore be applied to further individualize therapy in esophageal cancer. Einleitung Die neoadjuvante Radiochemotherapie (RT/CTx) wurde primar fur das Plattenepithelcarcinom (SCC) der Speiserohre etabliert. Im eigenen Krankengut zeigte sich, dass auch Patienten mit lokal fortgeschrittenem Adenocarcinom der Speiserohre (AC) zu 30 % ein gutes Ansprechen haben und mit einer 3 Jahres Uberlebensrate von uber 80 % eine exzellente Prognose aufweisen. Um diese Patienten zu identifizieren, wurde der Gen-Polymorphismus von ERCC1 (rs11615), ein Schlussel-Enzym des Nucleotide Excision Repair (NER) Komplexes zum Schutz vor DNA inter- und intrastrand Crosslinks, bestimmt." @default.
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• W2896091328 date "2010-01-01" @default.
• W2896091328 modified "2023-09-23" @default.
• W2896091328 title "ERCC1 Gen-Polymorphismus zur Response- und Prognoseprädiktion einer neoadjuvanten Radiochemotherapie beim Adenocarcinom des Ösophagus Neoadjuvant radiochemotherapy in adenocarcinoma of the esophagus: Impact of ERCC1 gene polymorphisms for prediction of response and prognosis" @default.
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