Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896093126> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2896093126 abstract "Objective Exercise induces tissue blood flow redistribution, which decreases splanchnic circulation and leads to physiologic hypoxia in the gastrointestinal (GI) system and liver. We hypothesized that the oxygen redistribution in the internal organs is affected by exercise.
 Methods Twenty–four female 8-10wk ROSA26 ODD-Luc/+ mice (n= 6 per group) were used in this study. Three exercise models were conducted: (1) Moderate Exercise (ME): mice voluntarily swam for 30 min. (2) Heavy-intensity Exercise (HE): mice swam for 1.5 hours with 5% body weight loads attached to their tails. (3) Long-time Exercise (LE): mice voluntarily swam for 3 hours or till fatigue. Sedentary mice (SED) were used as controls. A hypoxic marker pimonidazole HCl was applied to detect tissue hypoxia. Pimonidazole HCl forms protein adducts when PO2 is under 10 mmHg. An hour after intraperitoneal injection of pimonidazole HCl (60 mg/kg body weight), the mice were anesthetized with isoflurane then sacrificed. The small intestine, colon, skeletal muscle, heart, liver, spleen and kidney specimens were fixed in 4% paraformaldehyde and stained with a specific monoclonal antibody against the pimonidazole HCl protein adducts to observe the hypoxic level of internal organs.
 Results (1) The distributions of immunostaining intensity of pimonidazole HCl were different among the internal organs. In the kidney, the renal tubules demonstrated staining for hypoxia. In the liver, the positive staining was radiating outwards from central veins. In the small intestine and colon, there was the retention of pimonidazole HCl from the crypt to villus. (2) In the ME group, the extent of hypoxia in the kidney, liver and colon was increased compared with the SED. We found the small intestine is susceptible to exercise-induced tissue hypoxia distribution. Exercise resulted in a markedly increased staining in the crypts, whereas decreased staining in the villus. Intensified positive stains were observed in the nuclei of hypoxic cells, mostly in ME and HE groups. (3) The heart, skeletal muscle and spleen were not shown positive staining pre- and post-exercise.
 Conclusions This study presented evidences that exercise induces the oxygen redistribution in the small intestine, colon, liver and kidney. The small intestine is susceptible to exercise induced physiological hypoxia." @default.
- W2896093126 created "2018-10-26" @default.
- W2896093126 creator A5010689255 @default.
- W2896093126 creator A5016035496 @default.
- W2896093126 creator A5051916679 @default.
- W2896093126 creator A5055538318 @default.
- W2896093126 creator A5078739680 @default.
- W2896093126 date "2018-10-04" @default.
- W2896093126 modified "2023-09-24" @default.
- W2896093126 title "PO-154 Exercise induced redistribution of oxygen in internal organs" @default.
- W2896093126 doi "https://doi.org/10.14428/ebr.v1i4.11783" @default.
- W2896093126 hasPublicationYear "2018" @default.
- W2896093126 type Work @default.
- W2896093126 sameAs 2896093126 @default.
- W2896093126 citedByCount "0" @default.
- W2896093126 crossrefType "journal-article" @default.
- W2896093126 hasAuthorship W2896093126A5010689255 @default.
- W2896093126 hasAuthorship W2896093126A5016035496 @default.
- W2896093126 hasAuthorship W2896093126A5051916679 @default.
- W2896093126 hasAuthorship W2896093126A5055538318 @default.
- W2896093126 hasAuthorship W2896093126A5078739680 @default.
- W2896093126 hasBestOaLocation W28960931261 @default.
- W2896093126 hasConcept C126322002 @default.
- W2896093126 hasConcept C134018914 @default.
- W2896093126 hasConcept C142724271 @default.
- W2896093126 hasConcept C158846371 @default.
- W2896093126 hasConcept C178790620 @default.
- W2896093126 hasConcept C185592680 @default.
- W2896093126 hasConcept C2775849017 @default.
- W2896093126 hasConcept C2780091579 @default.
- W2896093126 hasConcept C2780931953 @default.
- W2896093126 hasConcept C540031477 @default.
- W2896093126 hasConcept C71924100 @default.
- W2896093126 hasConcept C7836513 @default.
- W2896093126 hasConceptScore W2896093126C126322002 @default.
- W2896093126 hasConceptScore W2896093126C134018914 @default.
- W2896093126 hasConceptScore W2896093126C142724271 @default.
- W2896093126 hasConceptScore W2896093126C158846371 @default.
- W2896093126 hasConceptScore W2896093126C178790620 @default.
- W2896093126 hasConceptScore W2896093126C185592680 @default.
- W2896093126 hasConceptScore W2896093126C2775849017 @default.
- W2896093126 hasConceptScore W2896093126C2780091579 @default.
- W2896093126 hasConceptScore W2896093126C2780931953 @default.
- W2896093126 hasConceptScore W2896093126C540031477 @default.
- W2896093126 hasConceptScore W2896093126C71924100 @default.
- W2896093126 hasConceptScore W2896093126C7836513 @default.
- W2896093126 hasLocation W28960931261 @default.
- W2896093126 hasOpenAccess W2896093126 @default.
- W2896093126 hasPrimaryLocation W28960931261 @default.
- W2896093126 hasRelatedWork W2061588070 @default.
- W2896093126 hasRelatedWork W2072123989 @default.
- W2896093126 hasRelatedWork W2364498849 @default.
- W2896093126 hasRelatedWork W2374989077 @default.
- W2896093126 hasRelatedWork W2376679545 @default.
- W2896093126 hasRelatedWork W2380373523 @default.
- W2896093126 hasRelatedWork W2394211442 @default.
- W2896093126 hasRelatedWork W2408436344 @default.
- W2896093126 hasRelatedWork W2413046063 @default.
- W2896093126 hasRelatedWork W2413099304 @default.
- W2896093126 hasRelatedWork W2417221784 @default.
- W2896093126 hasRelatedWork W2418314221 @default.
- W2896093126 hasRelatedWork W2419288164 @default.
- W2896093126 hasRelatedWork W2425792303 @default.
- W2896093126 hasRelatedWork W2467119917 @default.
- W2896093126 hasRelatedWork W2589522610 @default.
- W2896093126 hasRelatedWork W2968402308 @default.
- W2896093126 hasRelatedWork W1569143095 @default.
- W2896093126 hasRelatedWork W1699465557 @default.
- W2896093126 hasRelatedWork W2417414955 @default.
- W2896093126 isParatext "false" @default.
- W2896093126 isRetracted "false" @default.
- W2896093126 magId "2896093126" @default.
- W2896093126 workType "article" @default.