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- W2896093944 abstract "Hemophilia A, characterized by impaired or absent expression of factor VIII, has long been managed via direct factor replacement. Functionally, factor VIII acts as a cofactor for factor IXa and allows activation of factor X, which, in combination with factor V, generates thrombin. Bispecific antibodies such as emicizumab are recombinant, monoclonal antibodies capable of recognizing and binding to two distinct antigenic targets simultaneously; emicizumab binds factors IXa and X, resulting in spatial approximation and activation of factor X, thereby mimicking the actions of factor VIII. Critically, the presence of antifactor VIII antibodies, for example, inhibitors, impacts neither the mechanism nor the efficacy by which emicizumab functions. The results and interim analyses of the emicizumab clinical trials, HAVEN 1, 2, 3, and 4, are additionally reviewed and discussed." @default.
- W2896093944 created "2018-10-26" @default.
- W2896093944 creator A5000917771 @default.
- W2896093944 creator A5033308534 @default.
- W2896093944 date "2018-10-01" @default.
- W2896093944 modified "2023-10-18" @default.
- W2896093944 title "The role of emicizumab, a bispecific factor IXa- and factor X-directed antibody, for the prevention of bleeding episodes in patients with hemophilia A" @default.
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- W2896093944 doi "https://doi.org/10.1177/2040620718799997" @default.
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