FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896095130> ?p ?o ?g. }

• W2896095130 abstract "The WW domain–containing oxidoreductase (WWOX) gene spans one of the most and highly expressed common fragile sites (CFS), FRA16D, which is known to be implicated in cancer. WWOX encodes a 46kDa adaptor protein, which contains two WW–domains at its N–terminus and a C–terminal catalytic domain homologous to short–chain dehydrogenase/reductase (SDR) family proteins. A high sequence conservation of WWOX orthologues from insects to rodents and ultimately humans suggest its significant role in physiology and homeostasis. Indeed, data obtained from several animal models including flies, fish and rodents demonstrate WWOX in vivo requirement and that its deregulation results in severe pathological consequences including growth retardation, post–natal lethality, neuropathy, metabolic disorders and tumorigenesis. Altogether, these findings set WWOX as an essential protein that is necessary to maintain normal cellular/physiological homeostasis. Here, we review and discuss the lessons and outcomes learned from modeling WWOX expression in vivo." @default.
• W2896095130 created "2018-10-26" @default.
• W2896095130 creator A5021249524 @default.
• W2896095130 creator A5087294256 @default.
• W2896095130 date "2018-10-10" @default.
• W2896095130 modified "2023-10-12" @default.
• W2896095130 title "Modeling WWOX Loss of Function in vivo: What Have We Learned?" @default.
• W2896095130 cites W1175692730 @default.
• W2896095130 cites W1485450463 @default.
• W2896095130 cites W1485476021 @default.
• W2896095130 cites W1567252236 @default.
• W2896095130 cites W1589229390 @default.
• W2896095130 cites W1606947195 @default.
• W2896095130 cites W1636503892 @default.
• W2896095130 cites W1759799165 @default.
• W2896095130 cites W1901250449 @default.
• W2896095130 cites W1917985521 @default.
• W2896095130 cites W196498318 @default.
• W2896095130 cites W1965360199 @default.
• W2896095130 cites W1965812209 @default.
• W2896095130 cites W1971294322 @default.
• W2896095130 cites W1971347682 @default.
• W2896095130 cites W1972836732 @default.
• W2896095130 cites W1973972117 @default.
• W2896095130 cites W1974993967 @default.
• W2896095130 cites W1976461898 @default.
• W2896095130 cites W1979538949 @default.
• W2896095130 cites W1982124514 @default.
• W2896095130 cites W1986217052 @default.
• W2896095130 cites W1987972154 @default.
• W2896095130 cites W1992628946 @default.
• W2896095130 cites W1993004107 @default.
• W2896095130 cites W1993775713 @default.
• W2896095130 cites W1995037363 @default.
• W2896095130 cites W1998008232 @default.
• W2896095130 cites W2002607580 @default.
• W2896095130 cites W2002959145 @default.
• W2896095130 cites W2006063063 @default.
• W2896095130 cites W2011207946 @default.
• W2896095130 cites W2016165461 @default.
• W2896095130 cites W2016791890 @default.
• W2896095130 cites W2030150987 @default.
• W2896095130 cites W2032748338 @default.
• W2896095130 cites W2034228525 @default.
• W2896095130 cites W2036180582 @default.
• W2896095130 cites W2038108954 @default.
• W2896095130 cites W2039633981 @default.
• W2896095130 cites W2043154679 @default.
• W2896095130 cites W2050690747 @default.
• W2896095130 cites W2052477944 @default.
• W2896095130 cites W2055007889 @default.
• W2896095130 cites W2059971436 @default.
• W2896095130 cites W2061182883 @default.
• W2896095130 cites W2062879143 @default.
• W2896095130 cites W2070554004 @default.
• W2896095130 cites W2070613675 @default.
• W2896095130 cites W2071545250 @default.
• W2896095130 cites W2072161589 @default.
• W2896095130 cites W2074174181 @default.
• W2896095130 cites W2075163418 @default.
• W2896095130 cites W2076974754 @default.
• W2896095130 cites W2077469182 @default.
• W2896095130 cites W2077725608 @default.
• W2896095130 cites W2081466880 @default.
• W2896095130 cites W2081885315 @default.
• W2896095130 cites W2082559623 @default.
• W2896095130 cites W2083436757 @default.
• W2896095130 cites W2083594471 @default.
• W2896095130 cites W2086333179 @default.
• W2896095130 cites W2086828713 @default.
• W2896095130 cites W2091199878 @default.
• W2896095130 cites W2092441446 @default.
• W2896095130 cites W2095288382 @default.
• W2896095130 cites W2098386097 @default.
• W2896095130 cites W2099143016 @default.
• W2896095130 cites W2101615830 @default.
• W2896095130 cites W2105566542 @default.
• W2896095130 cites W2106415712 @default.
• W2896095130 cites W2108925373 @default.
• W2896095130 cites W2108949452 @default.
• W2896095130 cites W2115704275 @default.
• W2896095130 cites W2117425241 @default.
• W2896095130 cites W2117622451 @default.
• W2896095130 cites W2119440519 @default.
• W2896095130 cites W2121508665 @default.
• W2896095130 cites W2121562958 @default.
• W2896095130 cites W2127295427 @default.
• W2896095130 cites W2130679565 @default.
• W2896095130 cites W2132633443 @default.
• W2896095130 cites W2136980073 @default.
• W2896095130 cites W2141985715 @default.
• W2896095130 cites W2142769596 @default.
• W2896095130 cites W2144651215 @default.
• W2896095130 cites W2144663664 @default.
• W2896095130 cites W2150185773 @default.
• W2896095130 cites W2150581545 @default.
• W2896095130 cites W2160084354 @default.
• W2896095130 cites W2162561014 @default.
• W2896095130 cites W2166732297 @default.
• W2896095130 cites W2171830224 @default.

• next