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- W2896111152 abstract "Cutaneous adverse drug reactions (cADRs) are unpredictable and may range from mild maculopapular exanthema (MPE) to life-threatening severe cutaneous adverse drug reactions (SCARs), including drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Increasing pharmacogenomic studies showed specific HLA alleles are strongly associated with cADRs. The pathogenic checkpoints of cADRs include genetic polymorphisms affecting the immune synapse of HLA/drugs/T cell receptor interactions, specific HLA loci, T cell-mediated responses, and drug metabolism. Recently, pharmacogenomic screening for specific HLA alleles or high-risk genes prior to drug prescriptions to prevent cADRs has been widely implemented in clinical practice." @default.
- W2896111152 created "2018-10-26" @default.
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- W2896111152 date "2018-10-20" @default.
- W2896111152 modified "2023-09-23" @default.
- W2896111152 title "Pharmacogenomics and Cutaneous Adverse Drug Reactions" @default.
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- W2896111152 doi "https://doi.org/10.1007/978-981-13-1489-6_3" @default.
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