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- W2896161765 abstract "Abstract Ddx3x encodes a DEAD box RNA helicase implicated in antiviral immunity and tumorigenesis. We find that hematopoietic Ddx3x deficiency in Vav1-Cre mice (Δ Ddx3x ) results in altered leukocyte composition of secondary lymphoid tissues, including a marked reduction in mature B cells. This paucity of peripheral B cells is associated with deficits in B-cell development in the bone marrow, including reduced frequencies of small pre-B cells. Bone marrow chimera experiments reveal a B-cell intrinsic effect of Ddx3x deletion. Mechanistically, Δ Ddx3x small pre-B cells exhibit lower expression of Brwd1 , a histone reader that restricts recombination at the immunoglobulin kappa ( Igk) locus. In fact, the B-cell deficits in Δ Ddx3x mice resemble those of Brwd1 mutant mice, and both strains of mice exhibit defective Igk rearrangement in small pre-B cells. The contribution of Ddx3x to Brwd1 expression and light chain rearrangement constitutes the first evidence of a role for an RNA helicase in promoting B-cell development." @default.
- W2896161765 created "2018-10-26" @default.
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- W2896161765 date "2018-10-25" @default.
- W2896161765 modified "2023-10-16" @default.
- W2896161765 title "<i>Ddx3x</i>regulates B-cell development and light chain recombination in mice" @default.
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- W2896161765 doi "https://doi.org/10.1101/452086" @default.
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