Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896162120> ?p ?o ?g. }
- W2896162120 endingPage "195" @default.
- W2896162120 startingPage "185" @default.
- W2896162120 abstract "Abstract Objectives To evaluate the cytotoxic activity of atractylodin and its potential effects on heme oxygenase (HO)-1 production, STAT1/3 phosporylation and major NF-κB protein expression in the cholangiocarcinoma-associated cell line CL-6. Methods Standard MTT assay was used for accessing antiproliferative activity on CL-6 cells. Normal human embryonic fibroblast (OUMS) cell was taken as control cell line. Colony formation and wound healing assay were conducted to access the effects of atractylodin on cell proliferation and directional migration activity of CL-6 cells. Western blot was used for evaluating levels of protein expression and phosphorylation. Key findings Atractylodin exhibited selective cytotoxicity towards CL-6 as compared with OUMS with IC50 of 216.8 (212.4-233.8) and 351.2 (345.7-359.5) μm [median (range)], respectively. Exposure to the compound dose-dependently inhibited colony formation ability and decreased wound closure potential of CL-6 cells. Atractylodin treatment suppressed HO-1 production in CL-6 cells. It dose-dependently inhibited STAT1/3 protein phosphorylation and moderately inhibited NF-κB (p50), NF-κB (p52), and NF-κB (p65) protein expression in both dose- and time-dependent manner. Conclusions Atractylodin exerts significant cytotoxic activity against CL-6 cells which may be linked to its suppressive effect on HO-1 production, STAT1/3 phosphorylation and expression of key NF-κB proteins." @default.
- W2896162120 created "2018-10-26" @default.
- W2896162120 creator A5002736566 @default.
- W2896162120 creator A5020039833 @default.
- W2896162120 creator A5070911108 @default.
- W2896162120 date "2018-10-15" @default.
- W2896162120 modified "2023-09-26" @default.
- W2896162120 title "Cytotoxic activity and molecular targets of atractylodin in cholangiocarcinoma cells" @default.
- W2896162120 cites W1863408313 @default.
- W2896162120 cites W1952507411 @default.
- W2896162120 cites W1969334180 @default.
- W2896162120 cites W1976777085 @default.
- W2896162120 cites W1981998280 @default.
- W2896162120 cites W1985071501 @default.
- W2896162120 cites W1992411964 @default.
- W2896162120 cites W1994216489 @default.
- W2896162120 cites W1995750237 @default.
- W2896162120 cites W2005137614 @default.
- W2896162120 cites W2007456673 @default.
- W2896162120 cites W2014237749 @default.
- W2896162120 cites W2017963086 @default.
- W2896162120 cites W2023154701 @default.
- W2896162120 cites W2024728867 @default.
- W2896162120 cites W2027260180 @default.
- W2896162120 cites W2027565234 @default.
- W2896162120 cites W2028544780 @default.
- W2896162120 cites W2029767217 @default.
- W2896162120 cites W2031983784 @default.
- W2896162120 cites W2033036320 @default.
- W2896162120 cites W2040706741 @default.
- W2896162120 cites W2047944979 @default.
- W2896162120 cites W2049788556 @default.
- W2896162120 cites W2055861869 @default.
- W2896162120 cites W2056955411 @default.
- W2896162120 cites W2075490622 @default.
- W2896162120 cites W2078867215 @default.
- W2896162120 cites W2081107312 @default.
- W2896162120 cites W2084240914 @default.
- W2896162120 cites W2088009538 @default.
- W2896162120 cites W2098196505 @default.
- W2896162120 cites W2098912300 @default.
- W2896162120 cites W2103117581 @default.
- W2896162120 cites W2117500094 @default.
- W2896162120 cites W2119841220 @default.
- W2896162120 cites W2129363220 @default.
- W2896162120 cites W2130771246 @default.
- W2896162120 cites W2132834292 @default.
- W2896162120 cites W2134887638 @default.
- W2896162120 cites W2141768848 @default.
- W2896162120 cites W2142381684 @default.
- W2896162120 cites W2145530136 @default.
- W2896162120 cites W2152002064 @default.
- W2896162120 cites W2153362704 @default.
- W2896162120 cites W2154598314 @default.
- W2896162120 cites W2163152706 @default.
- W2896162120 cites W2169930591 @default.
- W2896162120 cites W2170952146 @default.
- W2896162120 cites W2174256729 @default.
- W2896162120 cites W2184866463 @default.
- W2896162120 cites W2273880462 @default.
- W2896162120 cites W2333406882 @default.
- W2896162120 cites W2436134992 @default.
- W2896162120 doi "https://doi.org/10.1111/jphp.13024" @default.
- W2896162120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30324612" @default.
- W2896162120 hasPublicationYear "2018" @default.
- W2896162120 type Work @default.
- W2896162120 sameAs 2896162120 @default.
- W2896162120 citedByCount "15" @default.
- W2896162120 countsByYear W28961621202019 @default.
- W2896162120 countsByYear W28961621202020 @default.
- W2896162120 countsByYear W28961621202021 @default.
- W2896162120 countsByYear W28961621202022 @default.
- W2896162120 countsByYear W28961621202023 @default.
- W2896162120 crossrefType "journal-article" @default.
- W2896162120 hasAuthorship W2896162120A5002736566 @default.
- W2896162120 hasAuthorship W2896162120A5020039833 @default.
- W2896162120 hasAuthorship W2896162120A5070911108 @default.
- W2896162120 hasConcept C104317684 @default.
- W2896162120 hasConcept C109316439 @default.
- W2896162120 hasConcept C11960822 @default.
- W2896162120 hasConcept C1491633281 @default.
- W2896162120 hasConcept C153911025 @default.
- W2896162120 hasConcept C154317977 @default.
- W2896162120 hasConcept C185592680 @default.
- W2896162120 hasConcept C202751555 @default.
- W2896162120 hasConcept C2776415932 @default.
- W2896162120 hasConcept C2777730290 @default.
- W2896162120 hasConcept C2780381497 @default.
- W2896162120 hasConcept C2780783641 @default.
- W2896162120 hasConcept C502942594 @default.
- W2896162120 hasConcept C53227056 @default.
- W2896162120 hasConcept C54355233 @default.
- W2896162120 hasConcept C55493867 @default.
- W2896162120 hasConcept C62478195 @default.
- W2896162120 hasConcept C71924100 @default.
- W2896162120 hasConcept C81885089 @default.
- W2896162120 hasConcept C86803240 @default.
- W2896162120 hasConcept C95444343 @default.