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- W2896163957 abstract "ObjectiveChronic rhinosinusitis (CRS) is a heterogeneous disorder with distinct pathophysiologic mechanisms. Based on transcription factor expression and cytokine production patterns in different innate lymphoid cell (ILC) types, in parallel with those of adaptive CD4+ T-helper (TH) cells and CD8+ cytotoxic T (Tc) cells, new perspectives on endotypes of patients are emerging for the immune response deviation into type 1 (orchestrated by ILC1s and Tc1, and TH1 cells), type 2 (characterized by ILC2s and Tc2 and TH2 cells), and type 3 (mediated by ILC3s and Tc17 and TH17 cells). In addition, cluster analysis has been applied to endotyping of CRS in recent years, which has provided additional novel insights into CRS pathogenesis. This review assessed pathologic mechanisms of CRS based on type 1, 2, and 3 immune responses and how they inform us to begin to understand CRS endotypes. This review also assessed recent cluster analysis studies of CRS endotypes. The impact of endotype on therapeutic management of CRS also is summarized.Data SourcesReview of published literature.Study SelectionsRelevant literature concerning CRS endotypes and possible underlying mechanisms was obtained from a PubMed search and summarized.Results and ConclusionCRS with and without nasal polyps are composed of distinct endotypes with distinct deviated immune responses, pathogenic mechanisms, and different responses to medical and surgical treatment. An endotype of CRS with prominent type 2 immune responses is the best-studied endotype and generally can benefit from treatment with steroids and specific type 2 disrupting biologics." @default.
- W2896163957 created "2018-10-26" @default.
- W2896163957 creator A5025211942 @default.
- W2896163957 creator A5048712863 @default.
- W2896163957 creator A5056666751 @default.
- W2896163957 creator A5077497438 @default.
- W2896163957 date "2019-01-01" @default.
- W2896163957 modified "2023-10-16" @default.
- W2896163957 title "Pathophysiologic mechanisms of chronic rhinosinusitis and their roles in emerging disease endotypes" @default.
- W2896163957 cites W1506545754 @default.
- W2896163957 cites W1515845928 @default.
- W2896163957 cites W1564173692 @default.
- W2896163957 cites W1834829312 @default.
- W2896163957 cites W1885435857 @default.
- W2896163957 cites W1967918340 @default.
- W2896163957 cites W1968876836 @default.
- W2896163957 cites W1972109738 @default.
- W2896163957 cites W1973354423 @default.
- W2896163957 cites W1978596588 @default.
- W2896163957 cites W1992424351 @default.
- W2896163957 cites W2002980147 @default.
- W2896163957 cites W2004627112 @default.
- W2896163957 cites W2016928970 @default.
- W2896163957 cites W2019903015 @default.
- W2896163957 cites W2021002838 @default.
- W2896163957 cites W2025490382 @default.
- W2896163957 cites W2026583845 @default.
- W2896163957 cites W2027746633 @default.
- W2896163957 cites W2028195000 @default.
- W2896163957 cites W2032000795 @default.
- W2896163957 cites W2036400427 @default.
- W2896163957 cites W2036867429 @default.
- W2896163957 cites W2039467806 @default.
- W2896163957 cites W2043416239 @default.
- W2896163957 cites W2043793366 @default.
- W2896163957 cites W2046864860 @default.
- W2896163957 cites W2047349997 @default.
- W2896163957 cites W2051893458 @default.
- W2896163957 cites W2057320783 @default.
- W2896163957 cites W2061944578 @default.
- W2896163957 cites W2065753363 @default.
- W2896163957 cites W2070011856 @default.
- W2896163957 cites W2073054459 @default.
- W2896163957 cites W2074897148 @default.
- W2896163957 cites W2076807299 @default.
- W2896163957 cites W2079394385 @default.
- W2896163957 cites W2081748056 @default.
- W2896163957 cites W2086033558 @default.
- W2896163957 cites W2086914849 @default.
- W2896163957 cites W2095499340 @default.
- W2896163957 cites W2101959303 @default.
- W2896163957 cites W2104849185 @default.
- W2896163957 cites W2105088246 @default.
- W2896163957 cites W2105880697 @default.
- W2896163957 cites W2112970562 @default.
- W2896163957 cites W2122844960 @default.
- W2896163957 cites W2124204692 @default.
- W2896163957 cites W2124913216 @default.
- W2896163957 cites W2127834887 @default.
- W2896163957 cites W2128790793 @default.
- W2896163957 cites W2130792630 @default.
- W2896163957 cites W2137263528 @default.
- W2896163957 cites W2140843031 @default.
- W2896163957 cites W2151079173 @default.
- W2896163957 cites W2159913536 @default.
- W2896163957 cites W2160883911 @default.
- W2896163957 cites W2170299167 @default.
- W2896163957 cites W2266684950 @default.
- W2896163957 cites W2289316671 @default.
- W2896163957 cites W2289410164 @default.
- W2896163957 cites W2353825714 @default.
- W2896163957 cites W2398324829 @default.
- W2896163957 cites W2406998470 @default.
- W2896163957 cites W2462860861 @default.
- W2896163957 cites W2507811495 @default.
- W2896163957 cites W2519161146 @default.
- W2896163957 cites W2546443879 @default.
- W2896163957 cites W2560932310 @default.
- W2896163957 cites W2563444955 @default.
- W2896163957 cites W2563559467 @default.
- W2896163957 cites W2567558689 @default.
- W2896163957 cites W2588851298 @default.
- W2896163957 cites W2590607262 @default.
- W2896163957 cites W2591656030 @default.
- W2896163957 cites W2597696030 @default.
- W2896163957 cites W2624732076 @default.
- W2896163957 cites W2733069545 @default.
- W2896163957 cites W2747461977 @default.
- W2896163957 cites W2761846098 @default.
- W2896163957 cites W2766636923 @default.
- W2896163957 cites W2771981616 @default.
- W2896163957 cites W2776484396 @default.
- W2896163957 cites W2783845858 @default.
- W2896163957 cites W2786638638 @default.
- W2896163957 cites W2801852873 @default.
- W2896163957 cites W2805507506 @default.
- W2896163957 cites W2855311737 @default.
- W2896163957 cites W2883629029 @default.