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- W2896201077 abstract "Abstract Biomaterials developed to treat bone defects have classically focused on bone healing via direct, intramembranous ossification. In contrast, most bones in our body develop from a cartilage template via a second pathway called endochondral ossification. The unsolved clinical challenge to regenerate large bone defects has brought endochondral ossification into discussion as an alternative approach for bone healing. However, a biomaterial strategy for the regeneration of large bone defects via endochondral ossification is missing. Here we report on a biomaterial with a channel-like pore architecture to control cell recruitment and tissue patterning in the early phase of healing. In consequence of extracellular matrix alignment, CD146+ progenitor cell accumulation and restrained vascularization, a highly organized endochondral ossification process is induced in rats. Our findings demonstrate that a pure biomaterial approach has the potential to recapitulate a developmental bone growth process for bone healing. This might motivate future strategies for biomaterial-based tissue regeneration." @default.
- W2896201077 created "2018-10-26" @default.
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- W2896201077 date "2018-10-25" @default.
- W2896201077 modified "2023-10-14" @default.
- W2896201077 title "A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects" @default.
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- W2896201077 doi "https://doi.org/10.1038/s41467-018-06504-7" @default.
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