FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896203415> ?p ?o ?g. }

• W2896203415 abstract "Abstract Increasing evidence shows that cancer stem cells are responsible for drug resistance and relapse of tumors. In breast cancer, human epidermal growth factor receptor 2 (HER2) induces Herceptin resistance by inducing cancer stem cells. In the present study, we explored the effect of HER2 on cancer stem cells induction and drug sensitivity of ovarian cancer cell lines. First, we found that HER2 overexpression (HER2 OE) induced, while HER2 knockdown (HER2 KD) decreased CD44+/CD24− population. Consistently, HER2 expression was closely correlated with the sphere formation efficiency (SFE) of ovarian cancer cells. Second, we found that NFκB inhibition by specific inhibitor JSH23 or siRNA targetting subunit p65 dramatically impaired the induction of ovarian cancer stem cells by HER2, indicating that NFκB mediated HER2-induced ovarian cancer stem cells. Third, we found that HER2 KD significantly attenuated the tumorigenicity of ovarian cancer cells. Further, we found that HER2 inhibition increased drastically the sensitivity of ovarian cancer cells to doxorubicin (DOX) or paclitaxel (PTX). Finally, we examined the correlation between HER2 status and stem cell-related genes expression in human ovarian tumor tissues, and found that expressions of OCT4, COX2, and Nanog were higher in HER2 positive tumors than in HER2 negative tumors. Consistently, the 5-year tumor-free survival rate of HER2 positive patients was dramatically lower than HER2 negative patients. Taken together, our data indicate that HER2 decreases drug sensitivity of ovarian cancer cells via inducing stem cell-like property." @default.
• W2896203415 created "2018-10-26" @default.
• W2896203415 creator A5024519095 @default.
• W2896203415 creator A5062019794 @default.
• W2896203415 creator A5088731186 @default.
• W2896203415 creator A5090492098 @default.
• W2896203415 creator A5090558931 @default.
• W2896203415 date "2019-03-01" @default.
• W2896203415 modified "2023-10-14" @default.
• W2896203415 title "HER2 decreases drug sensitivity of ovarian cancer cells via inducing stem cell-like property in an NFκB-dependent way" @default.
• W2896203415 cites W1904221680 @default.
• W2896203415 cites W1964903539 @default.
• W2896203415 cites W2024145520 @default.
• W2896203415 cites W2048055813 @default.
• W2896203415 cites W2064416108 @default.
• W2896203415 cites W2080661875 @default.
• W2896203415 cites W2090229207 @default.
• W2896203415 cites W2096768863 @default.
• W2896203415 cites W2103315206 @default.
• W2896203415 cites W2104558660 @default.
• W2896203415 cites W2105261759 @default.
• W2896203415 cites W2105626146 @default.
• W2896203415 cites W2111511846 @default.
• W2896203415 cites W2115585914 @default.
• W2896203415 cites W2119909440 @default.
• W2896203415 cites W2128050375 @default.
• W2896203415 cites W2129883523 @default.
• W2896203415 cites W2137191387 @default.
• W2896203415 cites W2138173930 @default.
• W2896203415 cites W2142752401 @default.
• W2896203415 cites W2148685331 @default.
• W2896203415 cites W2151605875 @default.
• W2896203415 cites W2158569602 @default.
• W2896203415 cites W2170552969 @default.
• W2896203415 cites W2176904228 @default.
• W2896203415 cites W2260138955 @default.
• W2896203415 cites W2472105705 @default.
• W2896203415 cites W2520728648 @default.
• W2896203415 cites W2551391139 @default.
• W2896203415 cites W2586556497 @default.
• W2896203415 cites W2608872586 @default.
• W2896203415 cites W2739584564 @default.
• W2896203415 cites W2743740886 @default.
• W2896203415 cites W2771887395 @default.
• W2896203415 cites W2797521429 @default.
• W2896203415 doi "https://doi.org/10.1042/bsr20180829" @default.
• W2896203415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6422889" @default.
• W2896203415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30314995" @default.
• W2896203415 hasPublicationYear "2019" @default.
• W2896203415 type Work @default.
• W2896203415 sameAs 2896203415 @default.
• W2896203415 citedByCount "6" @default.
• W2896203415 countsByYear W28962034152020 @default.
• W2896203415 countsByYear W28962034152022 @default.
• W2896203415 crossrefType "journal-article" @default.
• W2896203415 hasAuthorship W2896203415A5024519095 @default.
• W2896203415 hasAuthorship W2896203415A5062019794 @default.
• W2896203415 hasAuthorship W2896203415A5088731186 @default.
• W2896203415 hasAuthorship W2896203415A5090492098 @default.
• W2896203415 hasAuthorship W2896203415A5090558931 @default.
• W2896203415 hasBestOaLocation W28962034151 @default.
• W2896203415 hasConcept C104317684 @default.
• W2896203415 hasConcept C107459253 @default.
• W2896203415 hasConcept C121608353 @default.
• W2896203415 hasConcept C126322002 @default.
• W2896203415 hasConcept C136302470 @default.
• W2896203415 hasConcept C145103041 @default.
• W2896203415 hasConcept C1491633281 @default.
• W2896203415 hasConcept C207701140 @default.
• W2896203415 hasConcept C2777292972 @default.
• W2896203415 hasConcept C2780427987 @default.
• W2896203415 hasConcept C2780932548 @default.
• W2896203415 hasConcept C28328180 @default.
• W2896203415 hasConcept C502942594 @default.
• W2896203415 hasConcept C54355233 @default.
• W2896203415 hasConcept C55427017 @default.
• W2896203415 hasConcept C55493867 @default.
• W2896203415 hasConcept C71924100 @default.
• W2896203415 hasConcept C86803240 @default.
• W2896203415 hasConcept C95444343 @default.
• W2896203415 hasConcept C96232424 @default.
• W2896203415 hasConceptScore W2896203415C104317684 @default.
• W2896203415 hasConceptScore W2896203415C107459253 @default.
• W2896203415 hasConceptScore W2896203415C121608353 @default.
• W2896203415 hasConceptScore W2896203415C126322002 @default.
• W2896203415 hasConceptScore W2896203415C136302470 @default.
• W2896203415 hasConceptScore W2896203415C145103041 @default.
• W2896203415 hasConceptScore W2896203415C1491633281 @default.
• W2896203415 hasConceptScore W2896203415C207701140 @default.
• W2896203415 hasConceptScore W2896203415C2777292972 @default.
• W2896203415 hasConceptScore W2896203415C2780427987 @default.
• W2896203415 hasConceptScore W2896203415C2780932548 @default.
• W2896203415 hasConceptScore W2896203415C28328180 @default.
• W2896203415 hasConceptScore W2896203415C502942594 @default.
• W2896203415 hasConceptScore W2896203415C54355233 @default.
• W2896203415 hasConceptScore W2896203415C55427017 @default.
• W2896203415 hasConceptScore W2896203415C55493867 @default.
• W2896203415 hasConceptScore W2896203415C71924100 @default.
• W2896203415 hasConceptScore W2896203415C86803240 @default.
• W2896203415 hasConceptScore W2896203415C95444343 @default.

• next