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- W2896209416 abstract "Chronic kidney disease shares many phenotypic similarities with premature aging, involving accelerated vascular disease and muscle wasting. Although it has been recognized that increased risk of cognitive impairment and dementia in chronic kidney disease, detailed and comprehensive characterization of brain aging, including cognitive functions, and structural brain differences (gray and white matter), in dialysis patients is lacking. Fifty-eight non-demented, independently living dialysis patients (mean age 59.7 ± 11.1 years) and 62 non-dialysis controls (mean age 63.8 ± 10.1 years) were recruited from a medical center and community. They underwent a battery of neuropsychological tests, brain MRI T1 imaging and diffusion tensor imaging (DTI). T1 imaging was processed and analyzed by Freesurfer. Subcortical volumes and vertex-wise cortical thickness were compared between dialysis patients and non-dialysis controls after adjusting for age, sex, ICV, diabetes and depression. Region of interests (ROI)-based DTI analysis were conducted using the Johns Hopkins University International Consortium of Brain Mapping (ICBM) white-matter atlas. Fractional anisotrophy (FAs) of 68 ROIs were compared between dialysis patients and non-dialysis controls. The average years on dialysis was 5.6 years. Dialysis patients showed significantly worse performance in attention/information processing speed and executive function adjusted for age, sex, education, diabetes and depression. Reduced total brain volume and subcortical volume including hippocampus and amygdala were found in dialysis patients. Vertex-wise analysis showed cortical thinning in middle frontal, lateral occipital and precuneus region (Fig. 1). Furthermore, decreased white matter integrity was found primarily in bilateral anterior thalamic tract, fronto-occipital fasciculus, forcep minor and uncinate tract after adjustment for age, sex, diabetes, depression and correction for multiple comparisons. Differences in cognitive functions, cortical volumes/thickness and white matter integrity associated with dialysis are also cognitive domains, brain structure changes associated with aging. In other words, non-demented dialysis patients present an accelerated brain aging phenotype even after taking into account effects of age, diabetes and depression ." @default.
- W2896209416 created "2018-10-26" @default.
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- W2896209416 date "2018-07-01" @default.
- W2896209416 modified "2023-10-16" @default.
- W2896209416 title "O1‐14‐05: ACCELERATED BRAIN AGING IN NON‐DEMENTED DIALYSIS PATIENTS" @default.
- W2896209416 doi "https://doi.org/10.1016/j.jalz.2018.06.3051" @default.
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