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• W2896231604 abstract "The constant demand for new antibiotic drugs has driven efforts by the scientific community to prospect for peptides with a broad spectrum of action. In this context, antimicrobial peptides (AMPs) have acquired great scientific importance in recent years due to their ability to possess antimicrobial and immunomodulatory activity. In the last two decades, plants have attracted the interest of the scientific community and industry as regards their potential as biofactories of heterologous proteins. One of the most promising approaches is the use of viral vectors to maximize the transient expression of drugs in the leaves of the plant Nicotiana benthamiana. Recently, the MagnifectionTM expression system was launched. This sophisticated commercial platform allows the assembly of the viral particle in leaf cells and the systemic spread of heterologous protein biosynthesis in green tissues caused by Agrobacterium tumefaciens gene delivery method. The system also presents increased gene expression levels mediated by potent viral expression machinery. These characteristics allow the mass recovery of heterologous proteins in the leaves of N. benthamiana in 8 to 10 days. This system was highly efficient for the synthesis of different classes of pharmacological proteins and contains enormous potential for the rapid and abundant biosynthesis of AMPs." @default.
• W2896231604 created "2018-10-26" @default.
• W2896231604 creator A5017904400 @default.
• W2896231604 creator A5024047935 @default.
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• W2896231604 creator A5077288508 @default.
• W2896231604 creator A5083414444 @default.
• W2896231604 creator A5085091185 @default.
• W2896231604 date "2019-01-01" @default.
• W2896231604 modified "2023-10-12" @default.
• W2896231604 title "Molecular farming of antimicrobial peptides: available platforms and strategies for improving protein biosynthesis using modified virus vectors" @default.
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• W2896231604 doi "https://doi.org/10.1590/0001-3765201820180124" @default.
• W2896231604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30365717" @default.
• W2896231604 hasPublicationYear "2019" @default.
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