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• W2896235985 endingPage "197" @default.
• W2896235985 startingPage "186" @default.
• W2896235985 abstract "Quinoline derivatives 2, 3, quinolinyl based pyrazolines 4a,b, 5 and quinolinyl pyrazolinyl thiazole hybrids 6a-d, 7a-c and 8a-d were synthesized and screened for their anti-proliferative activity against MCF-7, HeLa and DLD1 cancer cell lines as well as normal fibroblast WI-38. Most of the tested compounds showed promising anticancer activity in addition to their safety towards the normal cell line. Eight compounds eliciting superior cytotoxicity against DLD1 and safe to the normal cell line 2, 3, 5, 6a, 6b, 7b, 7c and 8a were evaluated for their efficacy as EGFR inhibitors. They revealed inhibitory activity at nanomolar level especially compounds 6b, 2 and 7c with IC50 (31.80, 37.07 and 42.52 nM) in comparison to Gefitinib (IC50 = 29.16 nM)." @default.
• W2896235985 created "2018-10-26" @default.
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• W2896235985 date "2019-03-01" @default.
• W2896235985 modified "2023-09-27" @default.
• W2896235985 title "Synthesis and anti-proliferative activity of some new quinoline based 4,5-dihydropyrazoles and their thiazole hybrids as EGFR inhibitors" @default.
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• W2896235985 doi "https://doi.org/10.1016/j.bioorg.2018.10.038" @default.
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• W2896235985 hasPublicationYear "2019" @default.
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