FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896243669> ?p ?o ?g. }

• W2896243669 endingPage "e215" @default.
• W2896243669 startingPage "e214" @default.
• W2896243669 abstract "Studies have shown demonstrable salivary glands diffusion-weighted (DW)-MRI changes between pre- and post-radiation (RT). We aim to determine whether the apparent diffusion coefficient (ADC), derived from (DW-MRI), can provide an early (mid-RT) non-invasive biomarkers of salivary glands injury and subsequent xerostomia. Our institutional database was retrospectively reviewed for oropharyngeal cancer (OPC) patients treated with definitive radiotherapy and had available pre- and mid-RT DW-MRI acquired in the same radiation treatment position using proper immobilization devices, following an institutional review board approval. Salivary glands (ipsilateral parotid (iPA), ipsilateral submandibular (iSM), contralateral parotid (cPA), contralateral submandibular (cSM) and sublingual (SL)) were manually segmented using T2 weighted sequences at the two-time points. These contours were subsequently propagated to the corresponding DW-MRI and were checked for proper alignment with the corresponding region of interest using a commercial image registration software (Velocity AI v3.0.1). The ADC maps were generated and planning CT scans and dose grids at mid-RT were retrieved and co-registered to MRIs. Mean ADC values and mean doses were extracted. Statistical analysis was conducted using non-parametric Wilcoxon signed-rank and Spearman’s tests. A total of 30 OPC patients were included. The cohort median age (IQR) was 59 years (53-63). Male gender 88% and white race 88% predominated. Tonsil and base of tongue represented the site of tumor origin in 58% and 42%, respectively. All patients had stage III-IV disease and 97% were HPV positive. Twenty-six patients received IMRT and four patients received IMPT. The median prescription RT dose was 70 Gy in 33 fractions. The median dose (IQR) to iPA, iSM, cPA, cSM, SL at mid-RT were 20 (14-28), 37 (35-45), 13 (10-20), 33 (27-38), 27 (20-30) Gy, respectively. 47% of patients developed xerostomia G≥2 at 3-month post-RT. Our results showed a statistically significant increase in mean ADC values at mid-RT in all ROIs compared to baseline values (p<0.01 for all). The highest percentage of increase in ADC was noted in iPA with average 30% increase from baseline values. A weak correlation between dose and delta ADC was noted for iPA (Spearman ρ= 0.25, p=0.2). Patients with xerostomia G≥2 at 3-month had a significantly higher increase of mean ADC of iPA and iSM at mid-RT compared with patients with xerostomia G<2 (62% vs 15%, p=0.02 for iPA, and 31% vs 10%, p=0.04 for iSM). Using recursive partitioning analysis, an increase of ADC >71% in iPA was identified as the most significant predictor of xerostomia G≥2 (p<0.0001). DW-MRI at mid-RT predicted radiation-induced salivary gland injury and subsequent xerostomia in OPC patients treated with radiotherapy and appears as a promising tool for adaptive RT applications after further validation of our results in future studies." @default.
• W2896243669 created "2018-10-26" @default.
• W2896243669 creator A5010610490 @default.
• W2896243669 creator A5017019374 @default.
• W2896243669 creator A5029301520 @default.
• W2896243669 creator A5031841254 @default.
• W2896243669 creator A5037236993 @default.
• W2896243669 creator A5038269812 @default.
• W2896243669 creator A5039915435 @default.
• W2896243669 creator A5040338252 @default.
• W2896243669 creator A5041869544 @default.
• W2896243669 creator A5044463623 @default.
• W2896243669 creator A5047111624 @default.
• W2896243669 creator A5061124523 @default.
• W2896243669 creator A5065514528 @default.
• W2896243669 creator A5066356201 @default.
• W2896243669 creator A5071409978 @default.
• W2896243669 creator A5081006000 @default.
• W2896243669 creator A5082810931 @default.
• W2896243669 date "2018-11-01" @default.
• W2896243669 modified "2023-09-26" @default.
• W2896243669 title "Diffusion-Weighted MRI As an Early Biomarker of Xerostomia in Oropharyngeal Cancer Patients Treated with Radiation Therapy" @default.
• W2896243669 doi "https://doi.org/10.1016/j.ijrobp.2018.07.747" @default.
• W2896243669 hasPublicationYear "2018" @default.
• W2896243669 type Work @default.
• W2896243669 sameAs 2896243669 @default.
• W2896243669 citedByCount "3" @default.
• W2896243669 countsByYear W28962436692019 @default.
• W2896243669 countsByYear W28962436692020 @default.
• W2896243669 countsByYear W28962436692021 @default.
• W2896243669 crossrefType "journal-article" @default.
• W2896243669 hasAuthorship W2896243669A5010610490 @default.
• W2896243669 hasAuthorship W2896243669A5017019374 @default.
• W2896243669 hasAuthorship W2896243669A5029301520 @default.
• W2896243669 hasAuthorship W2896243669A5031841254 @default.
• W2896243669 hasAuthorship W2896243669A5037236993 @default.
• W2896243669 hasAuthorship W2896243669A5038269812 @default.
• W2896243669 hasAuthorship W2896243669A5039915435 @default.
• W2896243669 hasAuthorship W2896243669A5040338252 @default.
• W2896243669 hasAuthorship W2896243669A5041869544 @default.
• W2896243669 hasAuthorship W2896243669A5044463623 @default.
• W2896243669 hasAuthorship W2896243669A5047111624 @default.
• W2896243669 hasAuthorship W2896243669A5061124523 @default.
• W2896243669 hasAuthorship W2896243669A5065514528 @default.
• W2896243669 hasAuthorship W2896243669A5066356201 @default.
• W2896243669 hasAuthorship W2896243669A5071409978 @default.
• W2896243669 hasAuthorship W2896243669A5081006000 @default.
• W2896243669 hasAuthorship W2896243669A5082810931 @default.
• W2896243669 hasConcept C121608353 @default.
• W2896243669 hasConcept C126322002 @default.
• W2896243669 hasConcept C126838900 @default.
• W2896243669 hasConcept C12868164 @default.
• W2896243669 hasConcept C142724271 @default.
• W2896243669 hasConcept C143409427 @default.
• W2896243669 hasConcept C149550507 @default.
• W2896243669 hasConcept C206041023 @default.
• W2896243669 hasConcept C2778496288 @default.
• W2896243669 hasConcept C2779744641 @default.
• W2896243669 hasConcept C2780395140 @default.
• W2896243669 hasConcept C2989005 @default.
• W2896243669 hasConcept C509974204 @default.
• W2896243669 hasConcept C70816921 @default.
• W2896243669 hasConcept C71924100 @default.
• W2896243669 hasConcept C72563966 @default.
• W2896243669 hasConceptScore W2896243669C121608353 @default.
• W2896243669 hasConceptScore W2896243669C126322002 @default.
• W2896243669 hasConceptScore W2896243669C126838900 @default.
• W2896243669 hasConceptScore W2896243669C12868164 @default.
• W2896243669 hasConceptScore W2896243669C142724271 @default.
• W2896243669 hasConceptScore W2896243669C143409427 @default.
• W2896243669 hasConceptScore W2896243669C149550507 @default.
• W2896243669 hasConceptScore W2896243669C206041023 @default.
• W2896243669 hasConceptScore W2896243669C2778496288 @default.
• W2896243669 hasConceptScore W2896243669C2779744641 @default.
• W2896243669 hasConceptScore W2896243669C2780395140 @default.
• W2896243669 hasConceptScore W2896243669C2989005 @default.
• W2896243669 hasConceptScore W2896243669C509974204 @default.
• W2896243669 hasConceptScore W2896243669C70816921 @default.
• W2896243669 hasConceptScore W2896243669C71924100 @default.
• W2896243669 hasConceptScore W2896243669C72563966 @default.
• W2896243669 hasIssue "3" @default.
• W2896243669 hasLocation W28962436691 @default.
• W2896243669 hasOpenAccess W2896243669 @default.
• W2896243669 hasPrimaryLocation W28962436691 @default.
• W2896243669 hasRelatedWork W1893545675 @default.
• W2896243669 hasRelatedWork W1966942012 @default.
• W2896243669 hasRelatedWork W2012157926 @default.
• W2896243669 hasRelatedWork W2139922175 @default.
• W2896243669 hasRelatedWork W2893547184 @default.
• W2896243669 hasRelatedWork W2933320214 @default.
• W2896243669 hasRelatedWork W3121142985 @default.
• W2896243669 hasRelatedWork W4200472895 @default.
• W2896243669 hasRelatedWork W4210447931 @default.
• W2896243669 hasRelatedWork W796729141 @default.
• W2896243669 hasVolume "102" @default.
• W2896243669 isParatext "false" @default.
• W2896243669 isRetracted "false" @default.
• W2896243669 magId "2896243669" @default.

• next