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• W2896259069 abstract "Toxoplasma gondii is one of the most successful human parasites, infecting nearly one-third of the total world population. T. gondii tachyzoites residing within parasitophorous vacuoles (PVs) can acquire fatty acids both via salvage from host cells and via de novo synthesis pathways for membrane biogenesis. However, although fatty acid fluxes are known to exist in this parasite, how fatty acids flow through Toxoplasma lipid metabolic organelles, especially mitochondria, remains unknown. In this study, we demonstrated that Toxoplasma expresses an active ankyrin repeat containing protein TgACBP2 to coordinate cardiolipin metabolism. Specifically, HMA acquisition resulting from heterologous functional expression of MAF1 rescued growth and lipid metabolism defects in ACBP2-deficient type II parasites, manifesting the complementary role of host mitochondria in parasite cardiolipin metabolism. This work highlights the importance of TgACBP2 in parasite cardiolipin metabolism and provides evidence for metabolic association of host mitochondria with T. gondii ." @default.
• W2896259069 created "2018-10-26" @default.
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• W2896259069 date "2018-11-07" @default.
• W2896259069 modified "2023-10-17" @default.
• W2896259069 title "Comprehensive Characterization of <i>Toxoplasma</i> Acyl Coenzyme A-Binding Protein TgACBP2 and Its Critical Role in Parasite Cardiolipin Metabolism" @default.
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• W2896259069 doi "https://doi.org/10.1128/mbio.01597-18" @default.
• W2896259069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199492" @default.
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