FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896264987> ?p ?o ?g. }

• W2896264987 abstract "Abstract Systemic and cytosolic delivery represents a grand challenge preventing many therapeutic proteins from clinical applications. Despite tremendous progresses in the past decade, most approaches generally lack the ability of triggered traceless protein release, require complicated formulation, and/or yield low protein loading. By using the protein as a crosslinker, here, a simple and general formulation affording protein nanogels (NG) with uniformed sizes and exceptionally high protein loading (>50%) is reported. By using the fine‐tuned bis‐ and monosubstituted maleamic anhydride‐amine chemistry for the crosslinking of the protein and a 4‐armed PEG‐MA 4 , the NG is implemented with a tandem pH‐programmed and traceless release character. The final NG, CDM‐MA‐NG , is stable under normal physiological conditions and effectively protects the crosslinked cargo cytochrome C from serum fouling, proteolytic and thermal degradation. In vitro, CDM‐MA‐NG exhibits a high level of cellular uptake and potent cancer cell killing only when incubated at pH 6.5, but not 7.4. Systemic administration of CDM‐MA‐NG leads to significantly inhibited tumor growth and extended survival rate. Given the abundance of the amine groups on protein surface, this work describes a universal platform for therapeutic protein formulation, and opens up enormous opportunities for the systemic, cytosolic, and traceless delivery of protein‐based nanomedicines." @default.
• W2896264987 created "2018-10-26" @default.
• W2896264987 creator A5003267672 @default.
• W2896264987 creator A5031795955 @default.
• W2896264987 creator A5045972734 @default.
• W2896264987 creator A5053435402 @default.
• W2896264987 creator A5074729923 @default.
• W2896264987 date "2018-10-10" @default.
• W2896264987 modified "2023-10-01" @default.
• W2896264987 title "Dynamic Covalent Bond‐Assisted Programmed and Traceless Protein Release: High Loading Nanogel for Systemic and Cytosolic Delivery" @default.
• W2896264987 cites W1593734817 @default.
• W2896264987 cites W1803620352 @default.
• W2896264987 cites W1911744880 @default.
• W2896264987 cites W1963907102 @default.
• W2896264987 cites W1969131096 @default.
• W2896264987 cites W1984548348 @default.
• W2896264987 cites W1987119060 @default.
• W2896264987 cites W1987907868 @default.
• W2896264987 cites W1992272185 @default.
• W2896264987 cites W1992995295 @default.
• W2896264987 cites W1999988109 @default.
• W2896264987 cites W2007205599 @default.
• W2896264987 cites W2041507823 @default.
• W2896264987 cites W2044050036 @default.
• W2896264987 cites W2054045589 @default.
• W2896264987 cites W2054087967 @default.
• W2896264987 cites W2056056909 @default.
• W2896264987 cites W2061948616 @default.
• W2896264987 cites W2073341588 @default.
• W2896264987 cites W2081306620 @default.
• W2896264987 cites W2088793182 @default.
• W2896264987 cites W2101132274 @default.
• W2896264987 cites W2104101539 @default.
• W2896264987 cites W2111430686 @default.
• W2896264987 cites W2117969524 @default.
• W2896264987 cites W2135198179 @default.
• W2896264987 cites W2150368578 @default.
• W2896264987 cites W2159227890 @default.
• W2896264987 cites W2173147935 @default.
• W2896264987 cites W2194607126 @default.
• W2896264987 cites W2255761790 @default.
• W2896264987 cites W2261220794 @default.
• W2896264987 cites W2321009915 @default.
• W2896264987 cites W2321481286 @default.
• W2896264987 cites W2327337032 @default.
• W2896264987 cites W2413643739 @default.
• W2896264987 cites W2485740051 @default.
• W2896264987 cites W2586816391 @default.
• W2896264987 cites W2590680367 @default.
• W2896264987 cites W2605944669 @default.
• W2896264987 cites W2611647652 @default.
• W2896264987 cites W2732191012 @default.
• W2896264987 cites W2754071011 @default.
• W2896264987 cites W2777631158 @default.
• W2896264987 cites W2787698051 @default.
• W2896264987 cites W2793437963 @default.
• W2896264987 cites W2794981326 @default.
• W2896264987 cites W2836754285 @default.
• W2896264987 doi "https://doi.org/10.1002/adfm.201805287" @default.
• W2896264987 hasPublicationYear "2018" @default.
• W2896264987 type Work @default.
• W2896264987 sameAs 2896264987 @default.
• W2896264987 citedByCount "35" @default.
• W2896264987 countsByYear W28962649872019 @default.
• W2896264987 countsByYear W28962649872020 @default.
• W2896264987 countsByYear W28962649872021 @default.
• W2896264987 countsByYear W28962649872022 @default.
• W2896264987 countsByYear W28962649872023 @default.
• W2896264987 crossrefType "journal-article" @default.
• W2896264987 hasAuthorship W2896264987A5003267672 @default.
• W2896264987 hasAuthorship W2896264987A5031795955 @default.
• W2896264987 hasAuthorship W2896264987A5045972734 @default.
• W2896264987 hasAuthorship W2896264987A5053435402 @default.
• W2896264987 hasAuthorship W2896264987A5074729923 @default.
• W2896264987 hasConcept C10138342 @default.
• W2896264987 hasConcept C12554922 @default.
• W2896264987 hasConcept C131779359 @default.
• W2896264987 hasConcept C150903083 @default.
• W2896264987 hasConcept C162324750 @default.
• W2896264987 hasConcept C178790620 @default.
• W2896264987 hasConcept C180577832 @default.
• W2896264987 hasConcept C181199279 @default.
• W2896264987 hasConcept C185592680 @default.
• W2896264987 hasConcept C192562407 @default.
• W2896264987 hasConcept C207001950 @default.
• W2896264987 hasConcept C21951064 @default.
• W2896264987 hasConcept C25938499 @default.
• W2896264987 hasConcept C2776964284 @default.
• W2896264987 hasConcept C2779149719 @default.
• W2896264987 hasConcept C54400483 @default.
• W2896264987 hasConcept C55493867 @default.
• W2896264987 hasConcept C86803240 @default.
• W2896264987 hasConcept C98539663 @default.
• W2896264987 hasConceptScore W2896264987C10138342 @default.
• W2896264987 hasConceptScore W2896264987C12554922 @default.
• W2896264987 hasConceptScore W2896264987C131779359 @default.
• W2896264987 hasConceptScore W2896264987C150903083 @default.
• W2896264987 hasConceptScore W2896264987C162324750 @default.
• W2896264987 hasConceptScore W2896264987C178790620 @default.
• W2896264987 hasConceptScore W2896264987C180577832 @default.

• next