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- W2896286069 abstract "Attempts to quantify pulmonary scleroproteins in recent years have failed to show changes of collagen or elastin in emphysema or fibrosis; the collagen content appears to be the same as in the normal lung. We think that the disagreemnt with the optical appearance under the light microscope depends on the inappropriate use of reference parameters, namely weight of dried tissue or DNA content used to express the biochemical values in the sample. We have measured the scleroprotein content of 20 unharmed human right lungs taken at necropsy after sudden death, and expressed the values in μg per unit of volume of peripheral lung tissue inflated and formalin-fixed at the pressure of 25 cmH2O. A significant inverse correlation has been demonstrated between age and total collagen content only if expressed in μg/cc. This is in agreement with the significant direct correlation of the specific volume of expanded lung parenchyma with age. The elastin content does not show any increase when expressed in μg/cc; on the contrary, when expressed in mg/g of dry tissue, a direct correlation between elastin content and aging is shown. Therefore, our results agree with the expected rarefaction of connective tissue in over-inflated senile lung and prompt us to adapt our method of analysis to the study of true lung emphysema as well." @default.
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- W2896286069 date "1981-01-01" @default.
- W2896286069 modified "2023-09-23" @default.
- W2896286069 title "BIOCHEMICAL MEASUREMENT OF LUNG CONNECTIVE TISSUE" @default.
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- W2896286069 doi "https://doi.org/10.1016/b978-0-08-027379-2.50009-0" @default.
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